Fecal Microbiota Transplantation — An Old Therapy Comes of Age
- 31 January 2013
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 368 (5), 474-475
- https://doi.org/10.1056/nejme1214816
Abstract
In 1958, doctors in Denver administered feces by enema to their patients with fulminant, life-threatening pseudomembranous enterocolitis.1 The goal of this infusion of donor feces (also termed fecal microbiota transplantation [FMT]) was to “re-establish the balance of nature” within the intestinal flora to correct the disruption caused by antibiotic treatment. They reported “immediate and dramatic” responses and concluded that “this simple yet rational therapeutic method should be given more extensive clinical evaluation.” During the ensuing 50 years, the association between Clostridium difficile infection and pseudomembranous enterocolitis was established, and effective antimicrobial treatments were identified. Despite these advances, C. difficile became . . .This publication has 9 references indexed in Scilit:
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