Functions and Therapeutic Roles of Exosomes in Cancer
Open Access
- 27 May 2014
- journal article
- review article
- Published by Frontiers Media SA in Frontiers in Oncology
- Vol. 4, 127
- https://doi.org/10.3389/fonc.2014.00127
Abstract
The role of exosomes in cancer development has become the focus of much research, due to the many emerging roles possessed by these microscopic messengers. Exosomes are ubiquitously released in to the extracellular milieu, and have been found to regulate immune system function, particularly in tumorigenesis, as well as conditioning future metastatic sites for the attachment and growth of tumor tissue. Through an interaction with a range of host tissues, exosomes are able to generate a pro-tumor environment that is essential for carcinogenesis. Herein, we discuss the contents of exosomes and their contribution to tumorigenesis, as well as their role in chemotherapeutic resistance and the development of novel cancer treatments and the identification of cancer biomarkers.Keywords
This publication has 91 references indexed in Scilit:
- Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through METNature Medicine, 2012
- Intercellular nanovesicle-mediated microRNA transfer: A mechanism of environmental modulation of hepatocellular cancer cell growthJournal of Hepatology, 2011
- Prostate cancer-derived urine exosomes: a novel approach to biomarkers for prostate cancerBritish Journal of Cancer, 2009
- The metastatic niche: adapting the foreign soilNature Reviews Cancer, 2009
- Endothelial expression of autocrine VEGF upon the uptake of tumor-derived microvesicles containing oncogenic EGFRProceedings of the National Academy of Sciences of the United States of America, 2009
- Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkersNature, 2008
- MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancerGynecologic Oncology, 2008
- Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cellsNature, 2007
- Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein deliveryLeukemia, 2006
- Tumour-derived exosomes and their role in cancer-associated T-cell signalling defectsBritish Journal of Cancer, 2005