Persistent Remodeling of Resistance Arteries in Type 2 Diabetic Patients on Antihypertensive Treatment
- 1 February 2004
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Hypertension
- Vol. 43 (2), 399-404
- https://doi.org/10.1161/01.hyp.0000112029.03691.e7
Abstract
We hypothesized that resistance arteries from diabetic patients with controlled hypertension have less remodeling than vessels from untreated hypertensive subjects. Eight normotensive subjects (aged 44±3 years, 3 men; values are mean±SEM), 19 untreated hypertensive subjects (46±2 years, 9 men), and 23 hypertensive subjects with type 2 diabetes mellitus under antihypertensive treatment (58±1 years, 15 men) were studied. Resistance arteries dissected from gluteal subcutaneous tissue were assessed on a pressurized myograph. Most diabetic patients (70%) were being treated with angiotensin-converting enzyme inhibitors. Although systolic blood pressure was still above the normotensive range in these patients (144±2 versus 150±3 mm Hg in hypertensive and 114±4 mm Hg in normotensive subjects), diastolic blood pressure was well controlled (83±2 mm Hg) and significantly lower compared with that in untreated hypertensives (100±1 mm Hg; P P P P P P P <0.05 versus normotensive controls), whereas endothelium-independent vasorelaxation was similar in all groups. Despite effective antihypertensive treatment, resistance arteries from hypertensive diabetic patients showed marked remodeling, greater than that of vessels from untreated, nondiabetic, hypertensive subjects, in agreement with the high cardiovascular risk of subjects suffering from both diabetes and hypertension.Keywords
This publication has 22 references indexed in Scilit:
- Arterial Stiffness Increases With Deteriorating Glucose Tolerance StatusCirculation, 2003
- Vascular Structural and Functional Changes in Type 2 Diabetes MellitusCirculation, 2002
- Endothelial dysfunction in small resistance arteries of patients with non-insulin-dependent diabetes mellitusJournal of Hypertension, 2001
- Small artery remodeling is the most prevalent (earliest?) form of target organ damage in mild essential hypertensionJournal of Hypertension, 2001
- Correlation of endothelial function in large and small arteries in human essential hypertension.Journal of Hypertension, 2001
- Association of systolic blood pressure with macrovascular and microvascular complications of type 2 diabetes (UKPDS 36): prospective observational studyBMJ, 2000
- Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38BMJ, 1998
- Stiffness Indexes β of the Common Carotid and Femoral Arteries Are Associated With Insulin Resistance in NIDDMDiabetes Care, 1998
- Progressive improvement in the structure of resistance arteries of hypertensive patients after 2 years of treatment with an angiotensin i-converting enzyme inhibitor comparison with effects of a ?-lockerAmerican Journal of Hypertension, 1995
- Effects of a beta-blocker or a converting enzyme inhibitor on resistance arteries in essential hypertension.Hypertension, 1994