Injectable and biodegradable hydrogels: gelation, biodegradation and biomedical applications
Top Cited Papers
- 24 November 2011
- journal article
- review article
- Published by Royal Society of Chemistry (RSC) in Chemical Society Reviews
- Vol. 41 (6), 2193-2221
- https://doi.org/10.1039/c1cs15203c
Abstract
Injectable hydrogels with biodegradability have in situ formability which in vitro/in vivo allows an effective and homogeneous encapsulation of drugs/cells, and convenient in vivo surgical operation in a minimally invasive way, causing smaller scar size and less pain for patients. Therefore, they have found a variety of biomedical applications, such as drug delivery, cell encapsulation, and tissue engineering. This critical review systematically summarizes the recent progresses on biodegradable and injectable hydrogels fabricated from natural polymers (chitosan, hyaluronic acid, alginates, gelatin, heparin, chondroitin sulfate, etc.) and biodegradable synthetic polymers (polypeptides, polyesters, polyphosphazenes, etc.). The review includes the novel naturally based hydrogels with high potential for biomedical applications developed in the past five years which integrate the excellent biocompatibility of natural polymers/synthetic polypeptides with structural controllability via chemical modification. The gelation and biodegradation which are two key factors to affect the cell fate or drug delivery are highlighted. A brief outlook on the future of injectable and biodegradable hydrogels is also presented (326 references).This publication has 325 references indexed in Scilit:
- Methods to assess stem cell lineage, fate and functionAdvanced Drug Delivery Reviews, 2010
- Cell-mediated Delivery and Targeted Erosion of Vascular Endothelial Growth Factor-Crosslinked HydrogelsMacromolecular Rapid Communications, 2010
- Injectable candidate sealants for fetal membrane repair: bonding and toxicity in vitroAmerican Journal of Obstetrics and Gynecology, 2010
- Peptide-directed self-assembly of hydrogelsActa Biomaterialia, 2009
- Self-assembling materials for therapeutic deliveryActa Biomaterialia, 2009
- Engineered extracellular matrices with cleavable crosslinkers for cell expansion and easy cell recoveryBiomaterials, 2008
- In vitro assessment of the pro-inflammatory potential of β-hairpin peptide hydrogelsBiomaterials, 2008
- Retention of in vitro and in vivo BMP-2 bioactivities in sustained delivery vehicles for bone tissue engineeringBiomaterials, 2008
- Hydrogel biomaterials: A smart future?Biomaterials, 2007
- The effect of the controlled release of basic fibroblast growth factor from ionic gelatin-based hydrogels on angiogenesis in a murine critical limb ischemic modelBiomaterials, 2007