Linking abnormal mitosis to the acquisition of DNA damage
Open Access
- 10 December 2012
- journal article
- review article
- Published by Rockefeller University Press in The Journal of cell biology
- Vol. 199 (6), 871-881
- https://doi.org/10.1083/jcb.201210040
Abstract
Cellular defects that impair the fidelity of mitosis promote chromosome missegregation and aneuploidy. Increasing evidence reveals that errors in mitosis can also promote the direct and indirect acquisition of DNA damage and chromosome breaks. Consequently, deregulated cell division can devastate the integrity of the normal genome and unleash a variety of oncogenic stimuli that may promote transformation. Recent work has shed light on the mechanisms that link abnormal mitosis with the development of DNA damage, how cells respond to such affronts, and the potential impact on tumorigenesis.Keywords
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