Prognostic Nutritional Index Predicts Postoperative Outcome in Colorectal Cancer
Top Cited Papers
- 25 July 2013
- journal article
- research article
- Published by Wiley in World Journal of Surgery
- Vol. 37 (11), 2688-2692
- https://doi.org/10.1007/s00268-013-2156-9
Abstract
Background The prognostic nutritional index (PNI), which is calculated based on the serum albumin concentration and peripheral blood lymphocyte count, is a useful tool for predicting short-term and long-term postoperative outcome in patients undergoing cancer surgery. However, few studies have investigated PNI in colorectal cancer surgery. We examined the ability of PNI to predict short- and long-term outcomes in patients with colorectal cancer. Methods This retrospective study included 365 patients who underwent resection for colorectal cancer. The prognostic nutritional status was calculated on the basis of admission data as follows: 10 × serum albumin (g/dl) + 0.005 × total lymphocyte count (per mm3). The primary outcomes measured were the impact of PNI on overall survival and postoperative complications. Results Kaplan–Meier analysis and the log rank test revealed that low PNI was significantly associated with poor survival (P < 0.0001). In multivariate analysis for survival, preoperative low PNI was an independent prognostic factor for poor survival: odds ratio: 2.25, 95 % confidence interval 1.42–3.59). Moreover, low PNI significantly correlated with the incidence of postoperative complications, especially serious ones. Conclusions Preoperative PNI is a useful predictor of postoperative complications and survival in patients with colorectal cancer.Keywords
This publication has 14 references indexed in Scilit:
- Nutritional predictors of postoperative outcome in pancreatic cancerBritish Journal of Surgery, 2010
- Prognostic nutritional Index: A tool to predict the biological aggressiveness of gastric carcinomaSurgery Today, 2010
- Preoperative systemic inflammation predicts postoperative infectious complications in patients undergoing curative resection for colorectal cancerBritish Journal of Cancer, 2009
- Preoperative C‐reactive protein as a prognostic and therapeutic marker for colorectal cancerJournal of Surgical Oncology, 2008
- Classification of Surgical ComplicationsAnnals of Surgery, 2004
- Colorectal cancer screening and surveillance: Clinical guidelines and rationale—Update based on new evidenceGastroenterology, 2003
- Systemic inflammatory response predicts survival following curative resection of colorectal cancerBritish Journal of Surgery, 2003
- Dilution and redistribution effects of rapid 2-litre infusions of 0.9% (w/v) saline and 5% (w/v) dextrose on haematological parameters and serum biochemistry in normal subjects: a double-blind crossover studyClinical Science, 2001
- Causes and mechanisms of hypoalbuminaemiaClinical Nutrition, 2001
- The treatment of hypoalbuminaemiaClinical Nutrition, 2001