Administration of cisplatin in three patients with carboplatin hypersensitivity: is skin testing useful?
- 1 March 2010
- journal article
- case report
- Published by Ovid Technologies (Wolters Kluwer Health) in Anti-Cancer Drugs
- Vol. 21 (3), 333-338
- https://doi.org/10.1097/cad.0b013e32833418c0
Abstract
Carboplatin is a chemotherapeutic agent approved in the first-line setting of numerous malignancies. Hypersensitivity to carboplatin has been reported in up to 44% of patients receiving this antineoplastic agent, usually occurring after several courses of treatment. The aim of this study was to determine the usefulness of skin tests in ruling out cross-reaction to cisplatin to continue platinum-based chemotherapy in patients who are responsive to these agents. Prick tests and intradermal tests with a series of dilutions of carboplatin and cisplatin were performed on three patients who had exhibited medium and severe hypersensitivity reactions to carboplatin. Prick tests were negative in both the antineoplastic agents. Intradermal tests with carboplatin were positive in all three patients and negative with cisplatin. In all patients, the administration of cisplatin instead of carboplatin was well tolerated without the need of premedication. In conclusion, intradermal skin tests can be a useful tool for detecting a potential cross-reaction between platinum salts. It allows safe administration of a different platinum agent in patients who seem to benefit from platinum-based therapy. Discontinuation of chemotherapy, desensitization protocols and steroid premedication can be avoided.Keywords
This publication has 42 references indexed in Scilit:
- Hypersensitivity Reactions to Chemotherapeutic DrugsClinical Reviews in Allergy & Immunology, 2003
- Systematic Review of First-Line Chemotherapy for Newly Diagnosed Postoperative Patients with Stage II, III, or IV Epithelial Ovarian CancerGynecologic Oncology, 2002
- Weekly Dosing of Carboplatin Increases Risk of Allergy in ChildrenJournal of Pediatric Hematology/Oncology, 2001
- Carboplatin Skin Testing: A Skin-Testing Protocol for Predicting Hypersensitivity to Carboplatin ChemotherapyJournal of Clinical Oncology, 2001
- Clinical Features of Hypersensitivity Reactions to CarboplatinJournal of Clinical Oncology, 1999
- Continued Chemosensitivity to Cisplatin/Carboplatin in Ovarian Carcinoma Despite Treatment with Multiple Prior Platinum-Based RegimensGynecologic Oncology, 1997
- Hypersensitivity reactions to carboplatin given to patients with relapsed ovarian carcinomaEuropean Journal of Cancer, 1994
- Hypersensitivity reactions to carboplatin. Report of two patients, review of the literature, and discussion of diagnostic procedures and managementCancer, 1994
- Carboplatin hypersensitivity: Case reports and review of the literatureEuropean Journal of Cancer, 1993
- Treatment of relapsed carcinoma of the ovary with cisplatin or carboplatin following initial treatment with these compoundsGynecologic Oncology, 1990