Noncultured Autologous Adipose-Derived Stem Cells Therapy for Chronic Radiation Injury
Open Access
- 1 January 2010
- journal article
- Published by Hindawi Limited in Stem Cells International
- Vol. 2010, 1-8
- https://doi.org/10.4061/2010/532704
Abstract
Increasing concern on chronic radiation injuries should be treated properly for life-saving improvement of wound management and quality of life. Recently, regenerative surgical modalities should be attempted with the use of noncultured autologous adipose-derived stem cells (ADSCs) with temporal artificial dermis impregnated and sprayed with local angiogenic factor such as basic fibroblast growth factor, and secondary reconstruction can be a candidate for demarcation and saving the donor morbidity. Autologous adipose-derived stem cells, together with angiogenic and mitogenic factor of basic fibroblast growth factor and an artificial dermis, were applied over the excised irradiated skin defect and tested for Patients who were uneventfully healed with minimal donor-site morbidity, which lasts more than 1.5 years.Keywords
Funding Information
- Japan Society for the Promotion of Science
This publication has 18 references indexed in Scilit:
- Emerging therapy for improving wound repair of severe radiation burns using local bone marrow-derived stem cell administrationsWound Repair and Regeneration, 2010
- Cultured and freshly isolated adipose tissue-derived cells: fat years for cardiac stem cell therapyEuropean Heart Journal, 2009
- Radiologic and nuclear events: contingency planning for hematologists/oncologistsPublished by American Society of Hematology ,2008
- A Basic Fibroblast Growth Factor Improves Lower Extremity Wound Healing With a Porcine-Derived Skin SubstituteJournal Of Trauma-Injury Infection and Critical Care, 2008
- Stem molecular signature of adipose-derived stromal cellsExperimental Cell Research, 2008
- Intracoronary administration of autologous adipose tissue-derived stem cells improves left ventricular function, perfusion, and remodelling after acute myocardial infarctionEuropean Heart Journal, 2007
- Radiation-Induced Late Effects in Two Affected Individuals of the Lilo Radiation AccidentRadiation Research, 2007
- Radiation Injury from a Fluoroscopic ProcedureNew England Journal of Medicine, 2004
- Human Adipose Tissue Is a Source of Multipotent Stem CellsMolecular Biology of the Cell, 2002
- Clinical and Hematological Aspects of 137CsHealth Physics, 1991