Cognitive function following stroke and vascular cognitive impairment
- 1 December 2006
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in Current Opinion in Neurology
- Vol. 19 (6), 559-564
- https://doi.org/10.1097/01.wco.0000247612.21235.d9
Abstract
This review of the cognitive status following stroke and vascular cognitive impairment starts by questioning the concept of vascular dementia and related concepts. Our position is that in many cases these labels promote a superficial conceptualization of an inherently complex and heterogeneous phenomenon hampering a more detailed understanding. After stroke or disease of the cerebral vasculature, the cognitive and emotional outcome is dependent on a combination of three factors with the relative importance differing between causes. First, focal damage may lead to selective impairments that are dependent on the localization of the (grey matter) lesion. Second, diffuse neuronal dysfunction produces a more uniform profile of a decrease in mental speed, memory problems, and reduced executive functioning. Third, cognitive outcome is further modulated – notably in terms of severity – by patient variables such as age, sex, premorbid level of functioning, and comorbidity (e.g. hypertension). The complex character of the cognitive repercussions of stroke can be better harnessed by employing modern neuropsychological assessment procedures. This allows both a detailed categorization of the patients for the selection and effectiveness of therapeutic intervention, as well as the construction of reliable prognostic models.Keywords
This publication has 48 references indexed in Scilit:
- Early cognitive impairment predicts long-term depressive symptoms and quality of life after strokeJournal of the Neurological Sciences, 2006
- Postmortem Examination of Vascular Lesions in Cognitive ImpairmentStroke, 2006
- Domain-specific cognitive recovery after first-ever stroke: A follow-up study of 111 casesJournal of the International Neuropsychological Society, 2005
- Restrictions of the Mini-Mental State Examination in acute strokeArchives of Clinical Neuropsychology, 2005
- The Effect of Different Diagnostic Criteria on the Prevalence and Incidence of Post-Stroke DementiaNeuroepidemiology, 2005
- The prognostic value of domain-specific cognitive abilities in acute first-ever strokeNeurology, 2005
- Should the Mini Mental State Examination be used to monitor dementia treatments?The Lancet, 1999
- Vascular cognitive disorderInternational Journal of Geriatric Psychiatry, 1999
- Mild Cognitive ImpairmentArchives of Neurology, 1999
- Prevalence and severity of cognitive impairment with and without dementia in an elderly populationThe Lancet, 1997