State of the Art Reviews: The Anti-Inflammatory Actions of Exercise Training
Open Access
- 1 May 2007
- journal article
- review article
- Published by SAGE Publications in American Journal of Lifestyle Medicine
- Vol. 1 (3), 220-235
- https://doi.org/10.1177/1559827607300283
Abstract
The list of diseases with a known inflammatory etiology is growing. Cardiovascular disease, osteoporosis, diabetes, geriatric cachexia, and Alzheimer's disease have all been shown to be linked to or exacerbated by aberrantly regulated inflammatory processes. Nevertheless, there is mounting evidence that those who are physically active, or who become physically active, have a reduction in biomarkers associated with chronic inflammation. There was strong early consensus that exercise-induced reductions in inflammation were explained by body mass index or body fatness, but recent studies provide support for the contention that exercise has body fat—independent anti-inflammatory effects. With few exceptions, the anti-inflammatory effects of exercise appear to occur regardless of age or the presence of chronic diseases. What remains unclear are the mechanisms by which exercise training induces these anti-inflammatory effects, but there are several intriguing possibilities, including release of endogenous products, such as heat shock proteins; selective reduction of visceral adipose tissue mass or reducing infiltration of adipocytes by macrophages; shift in immune cell phenotype; cross-tolerizing effects; or exercise-induced shifts in accessory proteins of toll-like receptor signaling. However, future research endeavors are likely to uncover additional potential mechanisms, and it could be some time before functional mechanisms are made clear. In summary, the potential anti-inflammatory influences of exercise training may provide a low-cost, readily available, and effective treatment for low-grade systemic inflammation and could contribute signifiecantly to the positive effects of exercise training on chronic disease.Keywords
This publication has 153 references indexed in Scilit:
- Effects of exercise training on 5 inflammatory markers associated with cardiovascular riskAmerican Heart Journal, 2006
- Justification for the Use of Statins in Primary Prevention: An Intervention Trial Evaluating Rosuvastatin (JUPITER)—Can C-Reactive Protein Be Used to Target Statin Therapy in Primary Prevention?The American Journal of Cardiology, 2006
- Effect of exercise training on C-reactive protein in postmenopausal breast cancer survivors: A randomized controlled trialBrain, Behavior, and Immunity, 2005
- Effect of six months' exercise training on C-reactive protein levels in healthy elderly subjectsJournal of the American College of Cardiology, 2004
- Inflammatory Markers and the Risk of Coronary Heart Disease in Men and WomenThe New England Journal of Medicine, 2004
- The association between cardiorespiratory fitness and C-reactive protein in subjects with the metabolic syndromeJournal of the American College of Cardiology, 2004
- Higher production of IL-8 in visceral vs. subcutaneous adipose tissue. Implication of nonadipose cells in adipose tissueAmerican Journal of Physiology-Endocrinology and Metabolism, 2004
- Exercise induces hepatosplanchnic release of heat shock protein 72 in humansJournal Of Physiology-London, 2002
- Reduction of the Plasma Concentration of C-Reactive Protein Following Nine Months of Endurance TrainingInternational Journal of Sports Medicine, 2000
- The Role of TNF-α in Human Adipose Tissue: Prevention of Weight Gain at the Expense of Insulin Resistance?Hormone and Metabolic Research, 1999