Intravitreal Amphotericin B Treatment of Candida Endophthalmitis

Abstract

• A 43-year-old heroin addict with Candida albicans endophthalmitis was treated with a single 5-μg intravitreal injection of amphotericin B. The diagnosis was confirmed by smears and cultures of a vitreous aspiration. The patient's accidental death seven weeks after treatment enabled us to obtain histopathologic evidence that the infection had been cured and that the amphotericin B had had no toxic effect on the retina. Intravitreal amphotericin B should be considered an important mode of treatment of Candida endophthalmitis. (Arch Ophthalmol 95:89-93, 1977)