Cerebral Microbleeds: A Review of Clinical, Genetic, and Neuroimaging Associations
Top Cited Papers
Open Access
- 1 January 2014
- journal article
- review article
- Published by Frontiers Media SA in Frontiers in Neurology
- Vol. 4, 205
- https://doi.org/10.3389/fneur.2013.00205
Abstract
Cerebral microbleeds (microbleeds) are small, punctuate hypointense lesions seen in T2* Gradient-Recall Echo (GRE) and Susceptibility-Weighted (SWI) Magnetic Resonance Imaging (MRI) sequences, corresponding to areas of hemosiderin breakdown products from prior microscopic hemorrhages. They occur in the setting of impaired small vessel integrity, commonly due to either hypertensive vasculopathy or cerebral amyloid angiopathy. Microbleeds are more prevalent in individuals with Alzheimer’s disease (AD) dementia and in those with both ischemic and hemorrhagic stroke. However they are also found in asymptomatic individuals, with increasing prevalence with age, particularly in carriers of the Apolipoprotein (APOE) ε4 allele. Other neuroimaging findings that have been linked with microbleeds include lacunar infarcts and white matter hyperintensities on MRI, and increased cerebral β-amyloid burden using 11C-PiB Positron Emission Tomography. The presence of microbleeds has been suggested to confer increased risk of incident intracerebral hemorrhage – particularly in the setting of anticoagulation – and of complications of immunotherapy for AD. Prospective data regarding the natural history and sequelae of microbleeds are currently limited, however there is a growing evidence base that will serve to inform clinical decision-making in the future.Keywords
This publication has 142 references indexed in Scilit:
- Multidentate 18F-Polypegylated Styrylpyridines As Imaging Agents for Aβ Plaques in Cerebral Amyloid Angiopathy (CAA)Journal of Medicinal Chemistry, 2011
- Distribution of white matter hyperintensity in cerebral hemorrhage and healthy agingZeitschrift für Neurologie, 2011
- Cerebral amyloid angiopathy pathology and cognitive domains in older personsAnnals of Neurology, 2010
- Spatial relation between microbleeds and amyloid deposits in amyloid angiopathyAnnals of Neurology, 2010
- Imaging cerebral microbleeds using susceptibility weighted imaging: One step toward detecting vascular dementiaJournal of Magnetic Resonance Imaging, 2009
- Identification of calcification with MRI using susceptibility‐weighted imaging: A case studyJournal of Magnetic Resonance Imaging, 2008
- Detection of isolated cerebrovascular β‐amyloid with pittsburgh compound BAnnals of Neurology, 2008
- Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's diseaseBrain, 2008
- Amyloid-β vaccination, but not nitro-nonsteroidal anti-inflammatory drug treatment, increases vascular amyloid and microhemorrhage while both reduce parenchymal amyloidNeuroscience, 2007
- Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound‐BAnnals of Neurology, 2004