Activation‐induced cell death in T cells
Top Cited Papers
- 12 May 2003
- journal article
- review article
- Published by Wiley in Immunological Reviews
- Vol. 193 (1), 70-81
- https://doi.org/10.1034/j.1600-065x.2003.00051.x
Abstract
Summary: A properly functioning immune system is dependent on programmed cell death at virtually every stage of lymphocyte development and activity. This review addresses the phenomenon of activation‐induced cell death (AICD) in T lymphocytes, in which activation through the T‐cell receptor results in apoptosis. AICD can occur in a cell‐autonomous manner and is influenced by the nature of the initial T‐cell activation events. It plays essential roles in both central and peripheral deletion events involved in tolerance and homeostasis, although it is likely that different forms of AICD proceed via different mechanisms. For example, while AICD in peripheral T cells is often caused by the induction of expression of the death ligand, Fas ligand (CD95 ligand, FasL), it does not appear to be involved in AICD in thymocytes. This and other mechanisms of AICD are discussed. One emerging model that may complement other forms of AICD involves the inducible expression of FasL by nonlymphoid tissues in response to activated T lymphocytes. Induction of nonlymphoid FasL in this manner may serve as a sensing mechanism for immune cell infiltration, which contributes to peripheral deletion.Keywords
This publication has 104 references indexed in Scilit:
- Peripheral Deletion of Autoreactive CD8 T Cells by Cross Presentation of Self-Antigen Occurs by a Bcl-2–inhibitable Pathway Mediated by BimThe Journal of Experimental Medicine, 2002
- Metalloproteinase Shedding of Fas Ligand Regulates β-Amyloid NeurotoxicityCurrent Biology, 2002
- Regulation of FasL by NF-κB and AP-1 in Fas-dependent Thymineless Death of Human Colon Carcinoma CellsPublished by Elsevier BV ,2000
- Bcl-2–Mediated Drug ResistanceThe Journal of Experimental Medicine, 1999
- Activation of the CD95 (APO-1/Fas) pathway in drug- and γ-irradiation-induced apoptosis of brain tumor cellsCell Death & Differentiation, 1998
- TRAIL/Apo-2-ligand-induced apoptosis in human T cellsEuropean Journal of Immunology, 1998
- Fas(CD95)/FasL interactions required for programmed cell death after T-cell activationNature, 1995
- Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomasNature, 1995
- lnterleukin-2 programs mouse αβ T lymphocytes for apoptosisNature, 1991
- A delayed-type hypersensitivity reaction initiated by a single T lymphocyteInflammation Research, 1981