Molecular mechanisms of durg inhibition of DNA gyrase
- 1 August 1996
- Vol. 18 (8), 661-671
- https://doi.org/10.1002/bies.950180810
Abstract
DNA gyrase, an enzyme unique to prokaryotes, has been implicated in almost all processes that involve DNA. Although efficient inhibitors of this protein have been known for more than 20 years, none of them have enjoyed prolonged pharmaceutical success. It is only recently that the mechanisms of inhibition for some of these classes of drugs have been established unequivocally by X‐ray crystallography. It is hoped that this detailed structural information will assist the design of novel, effective inhibitors of DNA gyrase.Keywords
This publication has 67 references indexed in Scilit:
- The Complex of DNA Gyrase and Quinolone Drugs with DNA Forms a Barrier to Transcription by RNA PolymeraseJournal of Molecular Biology, 1994
- Crystallization of Inhibitor Complexes of an N-Terminal 24 kDa Fragment of the DNA Gyrase B ProteinJournal of Molecular Biology, 1994
- Three-dimensional Model of Escherichia coli Gyrase B Subunit Crystallized in Two-dimensions on Novobiocin-Linked Phospholipid FilmsJournal of Molecular Biology, 1994
- The F Plasmid CcdB Protein Induces Efficient ATP-dependent DNA Cleavage by GyraseJournal of Molecular Biology, 1993
- Expression and analysis of two gyrB genes from the novobiocin producer, Streptomyces sphaeroidesMolecular Microbiology, 1993
- Cell killing by the F plasmid CcdB protein involves poisoning of DNA-topoisomerase II complexesJournal of Molecular Biology, 1992
- Neutron and light-scattering studies of DNA gyrase and its complex with DNAJournal of Molecular Biology, 1990
- DNA gyrase and its complexes with DNA: direct observation by electron microscopyCell, 1985
- Sites of reaction of Escherichia coli DNA gyrase on pBR322 in vivo as revealed by oxolinic acid-induced plasmid linearizationJournal of Molecular Biology, 1985
- STRUCTURAL STUDIES ON STREPTONIVICIN,1 A NEW ANTIBIOTICJournal of the American Chemical Society, 1955