Benzopyrans, Biphenyls and Xanthones from the Root ofGarcinia liniiand their Activity againstMycobacterium tuberculosis

Abstract

A new benzopyran, (S)-3-hydroxygarcibenzopyran, and three new biphenyls, garcibiphenyl C, garcibiphenyl D, garcibiphenyl E, together with thirteen known compounds have been additionally isolated from the root of Garcinia linii. The structures of these new compounds were determined through spectral analyses. Among the isolates, 1,7-dihydroxy-3-methoxyxanthone and 1,5-dihydroxy-3-methoxyxanthone showed antitubercular activities with MICs of 3.1 ± 0.5 and 6.3 ± 1.0 μg/mL against Mycobacterium tuberculosis 90 - 221 387 in vitro, respectively.