Apixaban or Enoxaparin for Thromboprophylaxis after Knee Replacement
- 6 August 2009
- journal article
- research article
- Published by Massachusetts Medical Society in The New England Journal of Medicine
- Vol. 361 (6), 594-604
- https://doi.org/10.1056/nejmoa0810773
Abstract
The optimal strategy for thromboprophylaxis after major joint replacement has not been established. Low-molecular-weight heparins such as enoxaparin predominantly target factor Xa but to some extent also inhibit thrombin. Apixaban, a specific factor Xa inhibitor, may provide effective thromboprophylaxis with a low risk of bleeding and improved ease of use.Keywords
This publication has 19 references indexed in Scilit:
- Rivaroxaban versus Enoxaparin for Thromboprophylaxis after Total Knee ArthroplastyThe New England Journal of Medicine, 2008
- Apixaban, an oral, direct and highly selective factor Xa inhibitor: in vitro, antithrombotic and antihemostatic studiesJournal of Thrombosis and Haemostasis, 2008
- Physician compliance with guidelines for deep-vein thrombosis prevention in total hip and knee arthroplastyCurrent Medical Research and Opinion, 2008
- The efficacy and safety of apixaban, an oral, direct factor Xa inhibitor, as thromboprophylaxis in patients following total knee replacementJournal of Thrombosis and Haemostasis, 2007
- Oral dabigatran etexilate vs. subcutaneous enoxaparin for the prevention of venous thromboembolism after total knee replacement: the RE‐MODEL randomized trialJournal of Thrombosis and Haemostasis, 2007
- Reduced hospital stay and narcotic consumption, and improved mobilization with local and intraarticular infiltration after hip arthroplasty: A randomized clinical trial of an intraarticular technique versus epidural infusion in 80 patientsActa Orthopaedica, 2007
- Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non‐surgical patientsJournal of Thrombosis and Haemostasis, 2005
- Comparison of Ximelagatran with Warfarin for the Prevention of Venous Thromboembolism after Total Knee ReplacementThe New England Journal of Medicine, 2003
- Incidence of symptomatic venous thromboembolism after different elective or urgent surgical proceduresThrombosis and Haemostasis, 2003
- The Value of ???Multimodal??? or ???Balanced Analgesia??? in Postoperative Pain TreatmentAnesthesia & Analgesia, 1993