Helicobacter pylori Recurrence in Developed and Developing Countries: Meta‐Analysis of 13C‐Urea Breath Test Follow‐Up after Eradication
- 14 January 2008
- journal article
- research article
- Published by Wiley in Helicobacter
- Vol. 13 (1), 56-61
- https://doi.org/10.1111/j.1523-5378.2008.00571.x
Abstract
Recurrence of Helicobacter pylori infection after eradication is rare in developed countries and more frequent in developing countries. Most recurrent cases are attributed to recrudescence (recolonization of the same strain within 12 months) rather than to reinfection (colonization with a new strain after more than 12 months). The aim of the study was to analyze recurrence rates in developed and developing countries and to deduce the relative roles of recrudescence and reinfection. The PubMed database was searched up to January 31, 2007 using the keywords "Helicobacter pylori" or "H. pylori" and "recurrence" or "recrudescence," or "reinfection." Only prospective case studies in adults that used the (13)C-urea breath test ((13)CUBT) were included. Meta-analyses were performed with statdirect Statistical software, version 2.6.1, StatsDirect Ltd, Chesire, UK. The literature search yielded 10 studies of H. pylori recurrence in developed countries (3014 patients followed for 24-60 months) and 7 studies in developing countries (2071 patients followed for 12-60 months). The calculated annual recurrence rates were 2.67% and 13.00%, respectively. Nested meta-analysis of cases with a longer follow-up after eradication revealed an annual recurrence rate of 1.45% (RR 0.54) in developed countries and 12.00% (RR 0.92) in developing countries. The similarity of the annual recurrence rates during the first year after eradication and the annual recurrence rates in the second year after successful eradication in developing countries supports reinfection as the main cause in the second period. Therefore, a different approach for follow-up of H. pylori eradication may be needed between developed and developing countries.Keywords
This publication has 24 references indexed in Scilit:
- Reinfection after successful eradication of Helicobacter pylori: a 2‐year prospective study in Alaska NativesAlimentary Pharmacology & Therapeutics, 2006
- Recurrence of Helicobacter pylori infection after several eradication therapies: long‐term follow‐up of 1000 patientsAlimentary Pharmacology & Therapeutics, 2006
- The Recurrence of Helicobacter pylori Infection: Incidence and Variables Influencing It. A Critical ReviewThe American Journal of Gastroenterology, 2005
- Eradication of Helicobacter pylori Can Be Accurately Confirmed 14 Days after Termination of Triple Therapy Using a High-Dose Citric Acid-Based 13C Urea Breath TestDigestion, 2005
- Recurrence of Helicobacter pylori infection 1 year after successful treatmentEuropean Journal of Gastroenterology & Hepatology, 2004
- High rates of recurrence and of transient reinfections of Helicobacter pylori in a population with high prevalence of infectionThe American Journal of Gastroenterology, 2003
- Five‐year follow‐up study after Helicobacter pylori eradication: Reinfection and peptic ulcer statusChinese Journal of Digestive Diseases, 2003
- Recurrence ofHelicobacter pyloriInfection after Eradication: Incidence and Variables Influencing ItScandinavian Journal of Gastroenterology, 1998
- Helicobacter pyloriReinfection Is Virtually Absent after Successful EradicationThe Journal of Infectious Diseases, 1997