Endothelial stomatal and fenestral diaphragms in normal vessels and angiogenesis
Open Access
- 2 July 2007
- journal article
- review article
- Published by Wiley in Journal of Cellular and Molecular Medicine
- Vol. 11 (4), 621-643
- https://doi.org/10.1111/j.1582-4934.2007.00075.x
Abstract
Vascular endothelium lines the entire cardiovascular system where performs a series of vital functions including the control of microvascular permeability, coagulation inflammation, vascular tone as well as the formation of new vessels via vasculogenesis and angiogenesis in normal and disease states. Normal endothelium consists of heterogeneous populations of cells differentiated according to the vascular bed and segment of the vascular tree where they occur. One of the cardinal features is the expression of specific subcellular structures such as plas-malemmal vesicles or caveolae, transendothelial channels, vesiculo-vacuolar organelles, endothelial pockets and fenestrae, whose presence define several endothelial morphological types. A less explored observation is the differential expression of such structures in diverse settings of angiogenesis. This review will focus on the latest developments on the components, structure and function of these specific endothelial structures in normal endothelium as well as in diverse settings of angiogenesis.Keywords
This publication has 164 references indexed in Scilit:
- Rapid vascular regrowth in tumors after reversal of VEGF inhibitionJCI Insight, 2006
- Angiogenesis in life, disease and medicineNature, 2005
- Angiogenesis in the human heart: Gene and cell therapyAngiogenesis, 2005
- Antibodies Specific to the Plasma Membrane of Rat Lung Microvascular EndotheliumExperimental Cell Research, 1997
- Human Retinoblastoma: A Morphological Study of Apoptotic, Leukocytic, and Vascular ElementsUltrastructural Pathology, 1997
- Endothelial fenestrae in the rat fetal cerebrumDevelopmental Brain Research, 1988
- Endothelial diaphragmed fenestrae: in vitro modulation by phorbol myristate acetate.The Journal of cell biology, 1986
- Amelanotic melanoma of the lung and brain with fenestrated intrinsic tumor capillariesSurgical Neurology, 1981
- On the diaphragm across fenestrae of capillary endotheliumJournal of Ultrastructure Research, 1969
- The diaphragm of capillary endothelial fenestrationsJournal of Ultrastructure Research, 1962