Transcranial Magnetic Resonance Imaging– Guided Focused Ultrasound Surgery of Brain Tumors
Top Cited Papers
Open Access
- 1 February 2010
- journal article
- Published by Ovid Technologies (Wolters Kluwer Health) in Neurosurgery
- Vol. 66 (2), 323-332
- https://doi.org/10.1227/01.neu.0000360379.95800.2f
Abstract
This work evaluated the clinical feasibility of transcranial magnetic resonance imaging–guided focused ultrasound surgery. Transcranial magnetic resonance imaging–guided focused ultrasound surgery offers a potential noninvasive alternative to surgical resection. The method combines a hemispherical phased-array transducer and patient-specific treatment planning based on acoustic models with feedback control based on magnetic resonance temperature imaging to overcome the effects of the cranium and allow for controlled and precise thermal ablation in the brain. In initial trials in 3 glioblastoma patients, multiple focused ultrasound exposures were applied up to the maximum acoustic power available. Offline analysis of the magnetic resonance temperature images evaluated the temperature changes at the focus and brain surface. We found that it was possible to focus an ultrasound beam transcranially into the brain and to visualize the heating with magnetic resonance temperature imaging. Although we were limited by the device power available at the time and thus seemed to not achieve thermal coagulation, extrapolation of the temperature measurements at the focus and on the brain surface suggests that thermal ablation will be possible with this device without overheating the brain surface, with some possible limitation on the treatment envelope. Although significant hurdles remain, these findings are a major step forward in producing a completely noninvasive alternative to surgical resection for brain disorders.Keywords
This publication has 50 references indexed in Scilit:
- MRI monitoring of heating produced by ultrasound absorption in the skull: In vivo study in pigsMagnetic Resonance in Medicine, 2004
- MRI-guided gas bubble enhanced ultrasound heating inin vivorabbit thighPhysics in Medicine & Biology, 2003
- Investigation of a large-area phased array for focused ultrasound surgery through the skullPhysics in Medicine & Biology, 2000
- Laser-induced thermotherapy of cerebral neoplasia under MR tomographic controlMinimally Invasive Therapy & Allied Technologies, 1998
- A precise and fast temperature mapping using water proton chemical shiftMagnetic Resonance in Medicine, 1995
- MRI-Guided Laser-Induced Interstitial Thermotherapy of Cerebral NeoplasmsJournal of Computer Assisted Tomography, 1994
- Effect of fever on recurrence rate of febrile convulsions.Archives of Disease in Childhood, 1989
- Early Experiences with Ultrasonic Irradiation of the Pallidofugal and Nigral Complexes in Hyperkinetic and Hypertonic DisordersJournal of Neurosurgery, 1959
- FOCAL DESTRUCTION OF NERVOUS TISSUE BY FOCUSED ULTRASOUND: BIOPHYSICAL FACTORS INFLUENCING ITS APPLICATIONThe Journal of Experimental Medicine, 1956
- Effects of high intensity ultrasound on the central nervous system of the catJournal of Comparative Neurology, 1955