Maspin: molecular mechanisms and therapeutic implications
- 1 July 2012
- journal article
- review article
- Published by Springer Science and Business Media LLC in Cancer and Metastasis Reviews
- Vol. 31 (3-4), 529-551
- https://doi.org/10.1007/s10555-012-9361-0
Abstract
Maspin, a non-inhibitory member of the serine protease inhibitor superfamily, has been characterized as a tumor suppressor gene in multiple cancer types. Among the established anti-tumor effects of Maspin are the inhibition of cancer cell invasion, attachment to extracellular matrices, increased sensitivity to apoptosis, and inhibition of angiogenesis. However, while significant experimental data support the role of Maspin as a tumor suppressor, clinical data regarding the prognostic implications of Maspin expression have led to conflicting results. This highlights the need for a better understanding of the context dependencies of Maspin in normal biology and how these are perturbed in the context of cancer. In this review, we outline the regulation and roles of Maspin in normal and developmental biology while discussing novel evidence and emerging theories related to its functions in cancer. We provide insight into the immense therapeutic potential of Maspin and the challenges related to its successful clinical translation.Keywords
This publication has 99 references indexed in Scilit:
- Hallmarks of Cancer: The Next GenerationCell, 2011
- Identification of phosphorylation sites on extracellular corneal epithelial cell maspinProteomics, 2011
- Focus on molecules: MaspinExperimental Eye Research, 2010
- PI3K pathway alterations in cancer: variations on a themeOncogene, 2008
- IFN‐γ regulation of vacuolar pH, cathepsin D processing and autophagy in mammary epithelial cellsJournal of Cellular Biochemistry, 2008
- Epigenetic silencing of maspin expression occurs early in the conversion of keratocytes to fibroblastsExperimental Eye Research, 2008
- Maspin augments proteasome inhibitor‐induced apoptosis in prostate cancer cellsJournal of Cellular Physiology, 2007
- Metastasis: recent discoveries and novel treatment strategiesThe Lancet, 2007
- Comparative biology of mouse versus human cells: modelling human cancer in miceNature Reviews Cancer, 2003
- Terminal Differentiation of Human Breast Cancer through PPARγMolecular Cell, 1998