Effect of parental obesity and gestational diabetes on child neuropsychological and behavioral development at 4 years of age: the Rhea mother–child cohort, Crete, Greece
- 3 January 2017
- journal article
- research article
- Published by Springer Science and Business Media LLC in European Child & Adolescent Psychiatry
- Vol. 26 (6), 703-714
- https://doi.org/10.1007/s00787-016-0934-2
Abstract
Studies have suggested an association between maternal obesity pre-pregnancy and gestational diabetes (GDM) with impaired offspring neurodevelopment, but it is not clear if these associations are explained by shared familiar characteristics. We aimed to assess the associations of maternal and paternal obesity, maternal glucose intolerance in early pregnancy and GDM, with offspring neurodevelopment at 4 years of age. We included 772 mother–child pairs from the “Rhea” Mother–Child cohort in Crete, Greece. Data on maternal/paternal body mass index (BMI) and maternal fasting serum samples for glucose and insulin measurements were collected at 12 weeks of gestation. GDM screening was performed at 24–28 weeks. Neurodevelopment at 4 years was assessed using the McCarthy Scales of Children’s Abilities. Behavioral difficulties were assessed by Strengths and Difficulties Questionnaire and Attention Deficit Hyperactivity Disorder Test. Multivariate linear regression analyses showed that maternal obesity was associated with a significant score reduction in general cognitive ability (β-coeff −4.03, 95% CI: −7.08, −0.97), perceptual performance (β-coeff −4.60, 95% CI: −7.74, −1.47), quantitative ability (β-coeff −4.43, 95% CI: −7.68, −1.18), and executive functions (β-coeff −4.92, 95% CI: −8.06, −1.78) at 4 years of age, after adjustment for several confounders and paternal BMI. Maternal obesity was also associated with increased behavioral difficulties (β-coeff 1.22, 95% CI: 0.09, 2.34) and ADHD symptoms (β-coeff 4.28, 95% CI: 1.20, 7.36) at preschool age. Paternal obesity maternal glucose intolerance in early pregnancy and GDM was not associated with child neurodevelopment. These findings suggest that maternal obesity may impair optimal child neurodevelopment at preschool age independently of family shared characteristics.Keywords
Funding Information
- European Commission-European Social Fund (MIS349580)
This publication has 32 references indexed in Scilit:
- Pre-Pregnancy Body Mass Index in Relation to Infant Birth Weight and Offspring Overweight/Obesity: A Systematic Review and Meta-AnalysisPLOS ONE, 2013
- Maternal pre-pregnancy overweight and obesity, and child neuropsychological development: two Southern European birth cohort studiesInternational Journal of Epidemiology, 2013
- Maternal and offspring fasting glucose and type 2 diabetes-associated genetic variants and cognitive function at age 8: a Mendelian randomization study in the Avon Longitudinal Study of Parents and ChildrenBMC Medical Genetics, 2012
- Associations of Existing Diabetes, Gestational Diabetes, and Glycosuria with Offspring IQ and Educational Attainment: The Avon Longitudinal Study of Parents and ChildrenExperimental Diabetes Research, 2012
- Pre‐pregnancy and pregnancy obesity and neurodevelopmental outcomes in offspring: a systematic reviewObesity Reviews, 2011
- Intrauterine Effects of Maternal Prepregnancy Overweight on Child Cognition and Behavior in 2 CohortsPediatrics, 2011
- Childhood cognitive ability: relationship to gestational diabetes mellitus in IndiaDiabetologia, 2010
- Maternal blood glucose in diabetic pregnancies and cognitive performance in offspring in young adulthood: a Danish cohort studyDiabetic Medicine, 2010
- Diet‐induced obesity in female mice leads to peroxidized lipid accumulations and impairment of hippocampal neurogenesis during the early life of their offspringThe FASEB Journal, 2009
- Cognitive Function and Army Rejection Rate in Young Adult Male Offspring of Women With DiabetesDiabetes Care, 2007