Adamantine epithelioma has long been known and well described as an entity. Excellent case reports have appeared in the American literature with reviews of continental papers, but no large number of cases has been presented. Because of this and the high percentage of recurrences after a primary operation, a series of thirty-five cases is herein reported together with the discussion of the differential diagnosis of central cystic tumors of the jaws and certain observations on their histogenesis. This series is based on the records of the Surgical Pathological Laboratory of the Johns Hopkins Hospital and includes patients from the wards of the Department of Surgery, from the private clinic of Dr. Joseph Colt Bloodgood, together with a scattering of cases from other sources referred to this laboratory for diagnosis. The jaws are a region in which both dentisty and surgery overlap with a resulting confusion of the boundaries of specialization.