Sources and Targets of Reactive Oxygen Species in Synaptic Plasticity and Memory
- 21 November 2006
- journal article
- review article
- Published by Mary Ann Liebert Inc in Antioxidants and Redox Signaling
- Vol. 9 (2), 233-44
- https://doi.org/10.1089/ars.2007.9.ft-8
Abstract
Increasing evidence suggests that reactive oxygen species (ROS), such as superoxide and hydrogen peroxide, act as necessary signaling molecules in processes underlying cognition. Moreover, ROS have been shown to be necessary in molecular process underlying signal transduction, synaptic plasticity, and memory formation. Research from several laboratories suggests that NADPH oxidase is an important source of superoxide in the brain. Evidence is presented here to show that ROS are in fact important signaling molecules involved in synaptic plasticity and memory formation. Moreover, evidence that the NADPH oxidase complex is a key regulator of ROS generation in synaptic plasticity and memory formation is discussed. Understanding redox signaling in the brain, including the sources and molecular targets of ROS, are important for a full understanding of the signaling pathways that underlie synaptic plasticity and memory. Knowledge of ROS function in the brain also is critical for understanding aging and neurodegenerative diseases of the brain given that several of these disorders, including Alzheimer's disease and Parkinson disease, may be exacerbated by the unregulated generation of ROS.Keywords
This publication has 129 references indexed in Scilit:
- Synaptic Plasticity Deficits and Mild Memory Impairments in Mouse Models of Chronic Granulomatous DiseaseMolecular and Cellular Biology, 2006
- Molecular composition and regulation of the Nox family NAD(P)H oxidasesBiochemical and Biophysical Research Communications, 2005
- Biochemical mechanisms for translational regulation in synaptic plasticityNature Reviews Neuroscience, 2004
- GTPases and reactive oxygen species: switches for killing and signalingJournal of Cell Science, 2004
- Participation of NMDA‐mediated phosphorylation and oxidation of neurogranin in the regulation of Ca2+‐ and Ca2+/calmodulin‐dependent neuronal signaling in the hippocampusJournal of Neurochemistry, 2003
- Phosphatidylinositol 3-kinase: a molecule mediating BDNF-dependent spatial memory formationMolecular Psychiatry, 2003
- A Role for ERK MAP Kinase in Physiologic Temporal Integration in Hippocampal Area CA1Learning & Memory, 2003
- Peroxynitrite-Induced Tyrosine Nitration and Inhibition of Protein Kinase CBiochemical and Biophysical Research Communications, 2001
- Sources of Reactive Oxygen Species Production in Excitotoxin-Stimulated Cerebellar Granule CellsBiochemical and Biophysical Research Communications, 1999
- Activation of nadph-oxidase by arachidonic acid involves phospholipase A2 in intact human neutrophils but not in the cell-free systemBiochemical and Biophysical Research Communications, 1986