Improved Outcomes With High-dose Isoniazid in Multidrug-resistant Tuberculosis Treatment in Haiti
Open Access
- 29 January 2019
- journal article
- editorial
- Published by Oxford University Press (OUP) in Clinical Infectious Diseases
- Vol. 69 (4), 717-719
- https://doi.org/10.1093/cid/ciz039
Abstract
We report outcomes for a cohort of patients with multidrug-resistant tuberculosis who received high-dose isoniazid in Haiti. Patients who received high-dose isoniazid had a faster time to culture conversion and higher odds of successful outcome, despite high-level isoniazid resistance. This suggests high-dose isoniazid may have effectiveness even with phenotypic resistance.Keywords
Funding Information
- National Institutes of Health (R25TW009337, 5D43TW010062-04)
- Fogarty International Center
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