Diagnostic value of anti-microbial peptide, cathelicidin in congenital pneumonia
- 14 November 2014
- journal article
- research article
- Published by Taylor & Francis Ltd in The Journal of Maternal-Fetal & Neonatal Medicine
- Vol. 28 (18), 2197-2200
- https://doi.org/10.3109/14767058.2014.981806
Abstract
Objective: To evaluate the diagnostic value of anti-microbial peptide (cathelicidin), LL-37, in congenital pneumonia and its relation to 25 hydroxycholecalciferol [(25 OH)D] status. Methods: The study included 30 neonates with congenital pneumoniaandculture proven sepsis admitted to neonatal intensive care unit of Ain Shams University and 30 healthy neonates as control group. All neonates were subjected to history taking, clinical examination and measurement of serum 25(OH)D and cathelicidin. Results: Neonates with congenital pneumonia had significantly higher serum cathelicidin and lower serum 25(OH)D compared to controls. Serum cathelicidin was negatively correlated with Apgar score at 1 and 5 min and positively correlated with length of stay among patient group. Conclusion: Cut-off value of cathelicidin to diagnose congenital pneumonia was 17 pg/mmol with 93% sensitivity and 86% specificity. Neonates with congenital pneumonia had significantly high cathelicidin and low 25(OH)D suggesting a possible role of fetal 25(OH)D deficiency as predisposing factor for congenital pneumonia.Keywords
This publication has 12 references indexed in Scilit:
- Human defensins and LL-37 in mucosal immunityJournal of Leukocyte Biology, 2009
- Quantitative measurement of multifunctional quantum dot binding to cellular targets using flow cytometryCytometry Part A, 2008
- Antimicrobial peptides and the skin immune defense systemJournal of Allergy and Clinical Immunology, 2008
- Unexpected actions of vitamin D: new perspectives on the regulation of innate and adaptive immunityNature Clinical Practice Endocrinology & Metabolism, 2008
- Host Defense Peptide LL-37, in Synergy with Inflammatory Mediator IL-1β, Augments Immune Responses by Multiple PathwaysThe Journal of Immunology, 2007
- Vitamin D Deficiency in a Healthy Group of Mothers and Newborn InfantsClinical Pediatrics, 2007
- LL-37, the only human member of the cathelicidin family of antimicrobial peptidesBiochimica et Biophysica Acta (BBA) - Biomembranes, 2006
- The human cationic host defense peptide LL-37 mediates contrasting effects on apoptotic pathways in different primary cells of the innate immune systemJournal of Leukocyte Biology, 2006
- Neonatal pneumonia in developing countriesArchives of Disease in Childhood: Fetal & Neonatal, 2005
- Biology and clinical relevance of naturally occurring antimicrobial peptidesJournal of Allergy and Clinical Immunology, 2002