Sleep architecture, cocaine and visual learning
- 15 July 2008
- Vol. 103 (8), 1344-1352
- https://doi.org/10.1111/j.1360-0443.2008.02233.x
Abstract
Background Disturbances in sleep associated with chronic cocaine use may underlie abstinence‐related cognitive dysfunction. We hypothesized that sleep‐related cognitive function would be impaired in chronic cocaine users, and that this impairment would be associated with abstinence‐related changes in sleep architecture. Methods Twelve chronic cocaine users completed a 23‐day in‐patient study that included randomized, placebo‐controlled, cocaine self‐administration sessions. We report polysomnographic measurement of rapid eye‐movement (REM) sleep and slow‐wave activity, and performance on a visual texture discrimination task. Findings Progressive abstinence from cocaine was associated with characteristic changes in REM sleep. REM sleep was shortest on nights following cocaine use and rebounded in the first week of abstinence before diminishing with progressive abstinence, following a pattern opposite that of slow‐wave activity. Overnight visual learning was observed over the first night following 3 consecutive days of laboratory cocaine use; however, learning was not observed at 3 days or 17 days of abstinence. Across all points of abstinence, early‐night slow‐wave activity was associated strongly with non‐deterioration of visual performance overnight. Furthermore, overnight enhancement of visual performance was predicted by the co‐occurrence of sufficient early‐night slow‐wave activity and late night REM sleep, similar to results from studies in healthy subjects. Conclusions These results suggest that abstinence‐associated sleep‐dependent learning deficits are related to characteristic changes in sleep architecture, and promote the idea that treatments directed at sleep (‘somno‐tropic’ treatments) could be helpful in offsetting physiological consequences of cocaine abstinence.Keywords
This publication has 43 references indexed in Scilit:
- Topographic Imaging of Quantitative EEG in Response to Smoked Cocaine Self-Administration in HumansNeuropsychopharmacology, 2005
- Cognitive Performance by Humans During a Smoked Cocaine Binge-Abstinence CycleThe American Journal of Drug and Alcohol Abuse, 2005
- Local sleep and learningNature, 2004
- The restorative effect of naps on perceptual deteriorationNature Neuroscience, 2002
- Proposed supplements and amendments to ‘A Manual of Standardized Terminology, Techniques and Scoring System for Sleep Stages of Human Subjects’, the Rechtschaffen & Kales (1968) standardPsychiatry and Clinical Neurosciences, 2001
- Sleep Abnormalities During Abstinence in Alcohol-Dependent PatientsCNS Drugs, 2001
- The effects of cocaine on mood and sleep in cocaine-dependent males.Experimental and Clinical Psychopharmacology, 1999
- Polysomnographic and Subjective Sleep Predictors of Alcoholic RelapseAlcohol: Clinical and Experimental Research, 1998
- Dependence on REM Sleep of Overnight Improvement of a Perceptual SkillScience, 1994
- Assessment of Alcohol Withdrawal: the revised clinical institute withdrawal assessment for alcohol scale (CIWA‐Ar)British Journal of Addiction, 1989