A comparison between middle cerebral artery peak systolic velocity and amniotic fluid optical density at 450 nm in the prediction of fetal anemia
- 1 January 2003
- journal article
- research article
- Published by Elsevier BV in American Journal of Obstetrics and Gynecology
- Vol. 188 (1), 214-219
- https://doi.org/10.1067/mob.2003.63
Abstract
The purpose of this study was to compare fetal middle cerebral artery peak systolic velocity with amniotic fluid delta optical density at 450 nm in the prediction of fetal anemia. A prospective study that involved 28 singleton pregnancies that were at-risk for fetal anemia was carried out in a tertiary teaching hospital. Middle cerebral artery peak systolic velocity was measured immediately before the determination of deltaoptical density at 450 nm and fetal hemoglobin concentration. Sensitivities and predictive values for fetal anemia were examined. Fetal hemoglobin concentrations correlated significantly with middle cerebral artery peak systolic velocity (correlation coefficient, -0.77; P <.0001) and deltaoptical density at 450 nm zones (correlation coefficient, -0.56; P =.0025). Middle cerebral artery peak systolic velocity was >1.5 multiples of the median in 15 of 28 cases (54%); for this cutoff value, the sensitivity and positive-predictive values for a hemoglobin deficit of >-3SD were 75% and 60% and for a hemoglobin deficit of >-5SD were 100% and 47%, respectively. The corresponding values for deltaoptical density at 450-nm zone III (6/28 cases, 21%) were 0% (hemoglobin deficit, <-3SD) and 86% and 100% (hemoglobin deficit, <-5SD). Middle cerebral artery peak systolic velocity and amniotic fluid optical density at 450 nm are both useful in the prediction of fetal anemia. However, Doppler examination has the advantage of being a noninvasive method that can help reduce the number of invasive procedures in pregnancies that are at-risk for fetal anemia.Keywords
This publication has 18 references indexed in Scilit:
- Diagnostic Fetal Blood Sampling-Technique Related LossesFetal Diagnosis and Therapy, 1996
- The Relationship Between Peak Velocity in the Fetal Descending Aorta and Hematocrit in Rhesus IsoimmunizationPublished by Ovid Technologies (Wolters Kluwer Health) ,1995
- Fetal Venous, Arterial, and Intracardiac Blood Flows in Red Blood Cell IsoimmunizationPublished by Ovid Technologies (Wolters Kluwer Health) ,1995
- The use of ultrasonography and Doppler in the prediction of fetal haemolytic anaemia: a multivariate analysisBJOG: An International Journal of Obstetrics and Gynaecology, 1994
- Complications of fetal blood samplingAmerican Journal of Obstetrics and Gynecology, 1993
- Prediction of fetal anemia by measurement of the mean blood velocity in the fetal aortaAmerican Journal of Obstetrics and Gynecology, 1990
- Doppler Studies in Red Cell IsoimmunizationClinical Obstetrics and Gynecology, 1989
- Pulsed Doppler flow-velocity waveforms in the prediction of fetal hematocrit of the severely isoimmunized pregnancyAmerican Journal of Obstetrics and Gynecology, 1989
- Pulsed Doppler flow-velocity waveforms before and after intrauterine intravascular transfusion for severe erythroblastosis fetalisAmerican Journal of Obstetrics and Gynecology, 1988
- Have Liley charts outlived their usefulness?American Journal of Obstetrics and Gynecology, 1986