Function and mechanisms of TSLP/TSLPR complex in asthma and COPD
- 14 December 2011
- journal article
- review article
- Published by Wiley in Clinical and Experimental Allergy
- Vol. 42 (7), 994-1005
- https://doi.org/10.1111/j.1365-2222.2011.03919.x
Abstract
Thymic stromal lymphopoietin (TSLP) is a key pro-allergic cytokine that has recently been linked to chronic airway diseases, such as asthma and chronic obstructive pulmonary disease (COPD). High levels of TSLP were detected in bronchial mucosa of asthma and COPD patients suggesting TSLP's biological role beyond a signature 'Th2-favoring' or 'pro-allergic cytokine'. Besides inflammatory cells, airway structural cells produce and are targets of TSLP suggesting a potential autocrine loop that may have a profound effect on local inflammatory response and airway remodelling. This review sums up diverse mechanisms that mediate TSLP/TSLP receptor-signalling network in chronic airway diseases.This publication has 112 references indexed in Scilit:
- Thymic stromal lymphopoietin fosters human breast tumor growth by promoting type 2 inflammationThe Journal of Experimental Medicine, 2011
- Intratumor T helper type 2 cell infiltrate correlates with cancer-associated fibroblast thymic stromal lymphopoietin production and reduced survival in pancreatic cancerThe Journal of Experimental Medicine, 2011
- Mechanical injury polarizes skin dendritic cells to elicit a TH2 response by inducing cutaneous thymic stromal lymphopoietin expressionJournal of Allergy and Clinical Immunology, 2010
- Thymic stromal lymphopoietin-mediated STAT5 phosphorylation via kinases JAK1 and JAK2 reveals a key difference from IL-7–induced signalingProceedings of the National Academy of Sciences of the United States of America, 2010
- Sensing the outside world: TSLP regulates barrier immunityNature Immunology, 2010
- A new look at the pathogenesis of asthmaClinical Science, 2009
- Ozone and allergen exposure during postnatal development alters the frequency and airway distribution of CD25+ cells in infant rhesus monkeysToxicology and Applied Pharmacology, 2009
- Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cellsThe Journal of Experimental Medicine, 2007
- Inducible expression of the proallergic cytokine thymic stromal lymphopoietin in airway epithelial cells is controlled by NFκBProceedings of the National Academy of Sciences of the United States of America, 2007
- Human epithelial cells trigger dendritic cell–mediated allergic inflammation by producing TSLPNature Immunology, 2002