The Relationship between Vascular Function and the Autonomic Nervous System
- 1 January 2014
- journal article
- review article
- Published by The Editorial Committee of Annals of Vascular Diseases in Annals of Vascular Diseases
- Vol. 7 (2), 109-119
- https://doi.org/10.3400/avd.ra.14-00048
Abstract
Endothelial dysfunction and autonomic nervous system dysfunction are both risk factors for atherosclerosis. There is evidence demonstrating that there is a close interrelationship between these two systems. In hypertension, endothelial dysfunction affects the pathologic process through autonomic nervous pathways, and the pathophysiological process of autonomic neuropathy in diabetes mellitus is closely related with vascular function. However, detailed mechanisms of this interrelationship have not been clearly explained. In this review, we summarize findings concerning the interrelationship between vascular function and the autonomic nervous system from both experimental and clinical studies. The clarification of this interrelationship may provide more comprehensive risk stratification and a new effective therapeutic strategy against atherosclerosis.Keywords
This publication has 101 references indexed in Scilit:
- An evolving new paradigm: endothelial cells – conditional innate immune cellsJournal of Hematology & Oncology, 2013
- Long‐Term Renal Denervation Normalizes Disrupted Blood Pressure Circadian Rhythm and Ameliorates Cardiovascular Injury in a Rat Model of Metabolic SyndromeJournal of the American Heart Association, 2013
- Sympathetic activation and nitric oxide function in early hypertensionAmerican Journal of Physiology-Heart and Circulatory Physiology, 2012
- Sympathetic regulation of vascular function in health and diseaseFrontiers in Physiology, 2012
- Plasma norepinephrine is an independent predictor of vascular endothelial function with aging in healthy womenJournal of Applied Physiology, 2011
- Muscle Sympathetic Nerve Activity Is Related to a Surrogate Marker of Endothelial Function in Healthy IndividualsPLOS ONE, 2010
- Leukocyte – endothelial interactions in inflammationJournal of Cellular and Molecular Medicine, 2009
- The neurotransmitter dopamine modulates vascular permeability in the endotheliumJournal of Molecular Signaling, 2008
- Cross-Sectional Relations of Digital Vascular Function to Cardiovascular Risk Factors in the Framingham Heart StudyCirculation, 2008
- Increased Reactive Oxygen Species in Rostral Ventrolateral Medulla Contribute to Neural Mechanisms of Hypertension in Stroke-Prone Spontaneously Hypertensive RatsCirculation, 2004