Resistance to Activated Protein C as a Basis for Venous Thrombosis
Open Access
- 24 February 1994
- journal article
- research article
- Published by Massachusetts Medical Society in The New England Journal of Medicine
- Vol. 330 (8), 517-522
- https://doi.org/10.1056/nejm199402243300801
Abstract
In three families with various forms of venous thrombosis, we observed an apparently inherited poor response to the anticoagulant activated protein C (APC). The condition was due to a deficiency in a previously unrecognized anticoagulant factor that functioned as a cofactor to activated protein C.Keywords
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