Synthesis of Near-IR Fluorescent Oxazine Dyes with Esterase-Labile Sulfonate Esters
- 2 November 2011
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 13 (23), 6196-6199
- https://doi.org/10.1021/ol202619f
Abstract
Near-IR oxazine dyes are reported that contain sulfonate esters which are rapidly cleaved by esterase activity to unmask highly polar anionic sulfonates. Strategies for the synthesis of these dyes included the development of milder dye condensation conditions with improved functional compatibility and the use of an alkyl halide that allows for the introduction of esterase-labile sulfonates without the need for sulfonation of the target molecule.Keywords
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