Kidney disease in the elderly: update on recent literature
- 1 May 2008
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in Current Opinion in Nephrology and Hypertension
- Vol. 17 (3), 298-303
- https://doi.org/10.1097/mnh.0b013e3282f5dd90
Abstract
We review recent literature on the epidemiology and outcomes of chronic kidney disease in the elderly and discuss implications for management. Chronic kidney disease is common in the elderly and associated with substantial morbidity and mortality. The prognostic significance of a given level of estimated glomerular filtration rate, however, varies substantially by age. Estimates of the prevalence of chronic kidney disease at the population level and estimates glomerular filtration rate at the individual level are exquisitely sensitive to the methods used to arrive at these estimates. At present there is no clear consensus on the optimal approach to estimating glomerular filtration rate in elderly individuals in the clinical setting. Available evidence to guide management of chronic kidney disease is based largely on trials in younger individuals. It is unclear to what extent the results of these trials can be extrapolated to older individuals with chronic kidney disease. We advise caution in applying current guidelines to the care of the large number of individuals aged 70 years and older with chronic kidney disease. Ideally, the care of these patients should be individualized and carefully integrated with the management of other comorbid conditions and with patient preferences.Keywords
This publication has 58 references indexed in Scilit:
- Prevalence of Chronic Kidney Disease in the United StatesJAMA, 2007
- In chronic kidney disease staging the use of the chronicity criterion affects prognosis and the rate of progressionKidney International, 2007
- Age Affects Outcomes in Chronic Kidney DiseaseJournal of the American Society of Nephrology, 2007
- Cystatin C and Prognosis for Cardiovascular and Kidney Outcomes in Elderly Persons without Chronic Kidney DiseaseAnnals of Internal Medicine, 2006
- Kidney Function Predicts the Rate of Bone Loss in Older Individuals: The Cardiovascular Health StudyThe Journals of Gerontology: Series A, 2006
- Mortality Risk Stratification in Chronic Kidney DiseaseJournal of the American Society of Nephrology, 2006
- Moderate renal insufficiency at 70 years predicts mortalityQJM: An International Journal of Medicine, 2006
- Chronic Kidney Disease and the Risks of Death, Cardiovascular Events, and HospitalizationNew England Journal of Medicine, 2004
- Estimating the prevalence of renal insufficiency in seniors requiring long-term careKidney International, 2004
- Calibration and random variation of the serum creatinine assay as critical elements of using equations to estimate glomerular filtration rateAmerican Journal of Kidney Diseases, 2002