Tumor-Associated Monocytes/Macrophages Impair NK-Cell Function via TGFβ1 in Human Gastric Cancer
Open Access
- 28 February 2017
- journal article
- research article
- Published by American Association for Cancer Research (AACR) in Cancer Immunology Research
- Vol. 5 (3), 248-256
- https://doi.org/10.1158/2326-6066.cir-16-0152
Abstract
Patients with gastric cancer had few NK cells infiltrating their tumors, a condition associated with tumor progression and poor survival. These intratumoral NK cells were functionally impaired, due to the presence of TGFβ1 derived from tumor-associated monocytes/macrophages.Keywords
Other Versions
Funding Information
- National Key Research and Development Program of China (2016YFC1302200)
- National Natural Science Foundation of China (81502457, 81402355)
This publication has 28 references indexed in Scilit:
- Comprehensive analysis of the percentage of surface receptors and cytotoxic granules positive natural killer cells in patients with pancreatic cancer, gastric cancer, and colorectal cancerJournal of Translational Medicine, 2013
- Natural killer cells: role in local tumor growth and metastasisBiologics: Targets and Therapy, 2012
- Natural killer cells in non-hematopoietic malignanciesFrontiers in Immunology, 2012
- Transforming Growth Factor-β in the Gastrointestinal and Hepatic Tumor MicroenvironmentGastroenterology, 2011
- Human breast cancer cells enhance self tolerance by promoting evasion from NK cell antitumor immunityJCI Insight, 2011
- Profound Coordinated Alterations of Intratumoral NK Cell Phenotype and Function in Lung CarcinomaCancer Research, 2011
- Interleukin‐17‐educated monocytes suppress cytotoxic T‐cell function through B7‐H1 in hepatocellular carcinoma patientsEuropean Journal of Immunology, 2011
- Tumor-associated macrophages (TAM) as major players of the cancer-related inflammationJournal of Leukocyte Biology, 2009
- Prognostic implications of type and density of tumour-infiltrating lymphocytes in gastric cancerBritish Journal of Cancer, 2008
- CD4+CD25+ regulatory T cells inhibit natural killer cell functions in a transforming growth factor–β–dependent mannerThe Journal of Experimental Medicine, 2005