Segmental expression of Hox-2 homoeobox-containing genes in the developing mouse hindbrain
- 1 October 1989
- journal article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 341 (6241), 405-409
- https://doi.org/10.1038/341405a0
Abstract
The vertebrate hindbrain develops in a segmental pattern, with distinctive groups of neurons originating from different segments. We report here that members of the Hox-2 cluster of murine homoeobox genes are expressed in segment-specific patterns in the developing hindbrain, with successive genes having boundaries at two-segment intervals. These data indicate that Hox genes specify segment phenotype, a role analogous to that of their Drosophila homologues.Keywords
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