Radiation Cataractogenesis: A Review of Recent Studies
Top Cited Papers
- 1 July 2009
- journal article
- review article
- Published by Radiation Research Society in Radiation Research
- Vol. 172 (1), 1-9
- https://doi.org/10.1667/rr1688.1
Abstract
Ainsbury, E. A., Bouffler, S. D., Dörr, W., Graw, J., Muirhead, C. R., Edwards, A. A. and Cooper, J. Radiation Cataractogenesis: A Review of Recent Studies. Radiat. Res. 172, 1-9 (2009). The lens of the eye is recognized as one of the most radiosensitive tissues in the human body, and it is known that cataracts can be induced by acute doses of less than 2 Gy of low-LET ionizing radiation and less than 5 Gy of protracted radiation. Although much work has been carried out in this area, the exact mechanisms of radiation cataractogenesis are still not fully understood. In particular, the question of the threshold dose for cataract development is not resolved. Cataracts have been classified as a deterministic effect of radiation exposure with a threshold of approximately 2 Gy. Here we review the combined results of recent mechanistic and human studies regarding induction of cataracts by ionizing radiation. These studies indicate that the threshold for cataract development is certainly less than was previously estimated, of the order of 0.5 Gy, or that radiation cataractogenesis may in fact be more accurately described by a linear, no-threshold model.Keywords
This publication has 36 references indexed in Scilit:
- Risk of Cataract after Exposure to Low Doses of Ionizing Radiation: A 20-Year Prospective Cohort Study among US Radiologic TechnologistsAmerican Journal of Epidemiology, 2008
- The Etiology of Steroid CataractJournal of Ocular Pharmacology and Therapeutics, 2007
- Epidemiology of Cataract: Accomplishments over 25 years and Future DirectionsOphthalmic Epidemiology, 2007
- A REANALYSIS OF ATOMIC-BOMB CATARACT DATA, 2000???2002: A THRESHOLD ANALYSISHealth Physics, 2006
- Age-related cataractThe Lancet, 2005
- The genetic and molecular basis of congenital eye defectsNature Reviews Genetics, 2003
- A Review of the Epidemiologic Evidence Linking Ultraviolet Radiation and CataractsPublished by S. Karger AG ,2002
- Lenticular Opacities in Populations Exposed to Chronic Low-Dose-Rate Gamma Radiation from Radiocontaminated Buildings in TaiwanRadiation Research, 2001
- A clinical study of radiation cataract formation in adult life following gamma irradiation of the lens in early childhoodBritish Journal of Ophthalmology, 1997
- Radiation CataractJournal of Radiation Research, 1991