Targeting Immunity in End-Stage Renal Disease
- 25 February 2017
- journal article
- review article
- Published by S. Karger AG in American Journal of Nephrology
- Vol. 45 (4), 310-319
- https://doi.org/10.1159/000458768
Abstract
Background: Despite the stable incidence of end-stage renal disease (ESRD), it continues to be associated with an unacceptably high cardiovascular risk. Summary: ESRD is characterized by enhanced oxidative stress and severe inflammation, which boost cardiovascular risk, thus increasing cardiovascular-associated mortality rate. While substantial effort has been made in the technological innovation of dialytic techniques, few significant advances have been made to reduce inflammation in patients with ESRD. Indeed, this contrasts with the extensive scientific breakthroughs made in the basic field of science in targeting inflammation. There is thus a pressing need for clinical trials to test the effect of reducing inflammation in patients with ESRD. Here, we will revisit the negative effect of ESRD on inflammation and explore the impact of enhanced inflammation on cardiovascular outcomes and survival in patients with ESRD. Finally, we will discuss the need for clinical trials that target inflammation in ESRD, as well as weigh potential disadvantages and offer novel innovative approaches. Key Message: We will try to understand why the issue of inflammation has not been successfully addressed thus far in patients with ESRD, while at the same time weighing the potential disadvantages and offering novel innovative approaches for targeting inflammation in patients with ESRD.Keywords
This publication has 100 references indexed in Scilit:
- Low-Density Lipoprotein Modified by Myeloperoxidase in Inflammatory Pathways and Clinical StudiesMediators of Inflammation, 2013
- Antioxidants for chronic kidney diseaseEmergencias, 2012
- NFκB in the Development of Endothelial Activation and Damage in Uremia: An In Vitro ApproachPLOS ONE, 2012
- Telmisartan inhibits vascular dysfunction and inflammation via activation of peroxisome proliferator-activated receptor-γ in subtotal nephrectomized ratEuropean Journal of Pharmacology, 2012
- Galectin-1 research in T cell immunity: Past, present and futureClinical Immunology, 2012
- Innate immunity activation on biomaterial surfaces: A mechanistic model and coping strategiesAdvanced Drug Delivery Reviews, 2011
- Immunological Applications of Stem Cells in Type 1 DiabetesEndocrine Reviews, 2011
- Oral activated charcoal adsorbent (AST-120) ameliorates extent and instability of atherosclerosis accelerated by kidney disease in apolipoprotein E-deficient miceNephrology Dialysis Transplantation, 2011
- Complement anaphylatoxin C5a contributes to hemodialysis-associated thrombosisBlood, 2010
- Soluble CD14 Levels, Interleukin 6, and Mortality Among Prevalent Hemodialysis PatientsAmerican Journal of Kidney Diseases, 2009