Inflammation: Roles in Aging and Sarcopenia
- 1 November 2008
- journal article
- review article
- Published by Wiley in Journal of Parenteral and Enteral Nutrition
- Vol. 32 (6), 656-659
- https://doi.org/10.1177/0148607108324585
Abstract
Aging is associated with inflammatory chronic conditions such as obesity, cardiovascular disease, insulin resistance, and arthritis. Sarcopenia—muscle loss with aging—is multifactorial with contributing factors that may include loss of α-motor neuron input, changes in anabolic hormones, decreased intake of dietary protein, and decline in physical activity. Research findings suggest that sarcopenia is a smoldering inflammatory state driven by cytokines and oxidative stress. Elevated levels of interleukin-6 and C-reactive protein are often detected. Sarcopenic obesity manifests the added inflammatory burden of adiposity and associated adipokines. Potential interventions for sarcopenia include nutritional supplements, physical activity/resistance exercise, caloric restriction, anabolic hormones, anti-inflammatory agents, and antioxidants. A key question is whether sarcopenia is truly a distinct syndrome or a milder form of a cachexia continuum.Keywords
Funding Information
- National Institute of Diabetes and Digestive and Kidney Diseases (U13DK064190)
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