Tetraspanin Proteins Mediate Cellular Penetration, Invasion, and Fusion Events and Define a Novel Type of Membrane Microdomain
Top Cited Papers
- 1 November 2003
- journal article
- review article
- Published by Annual Reviews in Annual Review of Cell and Developmental Biology
- Vol. 19 (1), 397-422
- https://doi.org/10.1146/annurev.cellbio.19.111301.153609
Abstract
▪ Abstract This review summarizes key aspects of tetraspanin proteins, with a focus on the functional relevance and structural features of these proteins and how they are organized into a novel type of membrane microdomain. Despite the size of the tetraspanin family and their abundance and wide distribution over many cell types, most have not been studied. However, from studies of prototype tetraspanins, information regarding functions, cell biology, and structural organization has begun to emerge. Genetic evidence points to critical roles for tetraspanins on oocytes during fertilization, in fungi during leaf invasion, in Drosophila embryos during neuromuscular synapse formation, during T and B lymphocyte activation, in brain function, and in retinal degeneration. From structure and mutagenesis studies, we are beginning to understand functional subregions within tetraspanins, as well as the levels of connections among tetraspanins and their many associated proteins. Tetraspanin-enriched microdomains (TEMs) are emerging as entities physically and functionally distinct from lipid rafts. These microdomains now provide a context in which to evaluate tetraspanins in the regulation of growth factor signaling and in the modulation of integrin-mediated post-cell adhesion events. Finally, the enrichment of tetraspanins within secreted vesicles called exosomes, coupled with hints that tetraspanins may regulate vesicle fusion and/or fission, suggests exciting new directions for future research.Keywords
This publication has 147 references indexed in Scilit:
- Chinese Hamster Ovary Cell Motility to Fibronectin Is Modulated by the Second Extracellular Loop of CD9Published by Elsevier BV ,2002
- Localization of uroplakin Ia, the urothelial receptor for bacterial adhesin FimH, on the six inner domains of the 16 nm urothelial plaque particleJournal of Molecular Biology, 2002
- Analysis of the Roles of RGD-Binding Integrins, α4/α9 Integrins, α6 Integrins, and CD9 in the Interaction of the Fertilin β (ADAM2) Disintegrin Domain with the Mouse Egg Membrane1Biology of Reproduction, 2002
- CD9 Amino Acids Critical for Upregulation of Diphtheria Toxin BindingBiochemical and Biophysical Research Communications, 2001
- Analysis of the CD151·α3β1 Integrin and CD151·Tetraspanin Interactions by MutagenesisPublished by Elsevier BV ,2001
- CD81 Regulates Neuron-Induced Astrocyte Cell-Cycle ExitMolecular and Cellular Neuroscience, 2001
- Identification of Amino Acid Residues in CD81 Critical for Interaction with Hepatitis C Virus Envelope Glycoprotein E2Journal of Virology, 2000
- Possible role of coexpression of CD9 with membrane-anchored heparin-binding EGF-like growth factor and amphiregulin in cultured human keratinocyte growthJournal of Cellular Physiology, 1997
- Genomic structure and promoter analysis of the gene encoding MM3, a member of transmembrane 4 superfamilyGene, 1997
- CD9 of mouse brain is implicated in neurite outgrowth and cell migration in vitro and is associated with the α6/β1 integrin and the neural adhesion molecule L1Journal of Neuroscience Research, 1996