Caenorhabditis elegans SID-2 is required for environmental RNA interference
- 19 June 2007
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences of the United States of America
- Vol. 104 (25), 10565-10570
- https://doi.org/10.1073/pnas.0611282104
Abstract
In plants and in the nematode Caenorhabditis elegans, an RNAi signal can trigger gene silencing in cells distant from the site where silencing is initiated. In plants, this signal is known to be a form of dsRNA, and the signal is most likely a form of dsRNA in C. elegans as well. Furthermore, in C. elegans, dsRNA present in the environment or expressed in ingested bacteria is sufficient to trigger RNAi (environmental RNAi). Ingestion and soaking delivery of dsRNA has also been described for other invertebrates. Here we report the identification and characterization of SID-2, an intestinal luminal transmembrane protein required for environmental RNAi in C. elegans. SID-2, when expressed in the environmental RNAi defective species Caenorhabditis briggsae, confers environmental RNAi.Keywords
This publication has 34 references indexed in Scilit:
- Double-Stranded RNA Is Produced by Positive-Strand RNA Viruses and DNA Viruses but Not in Detectable Amounts by Negative-Strand RNA VirusesJournal of Virology, 2006
- Pristionchus pacificus: a well‐rounded nematodeBioEssays, 2006
- Silencing of the hydra serine protease inhibitorKazal1gene mimics the humanSPINK1pancreatic phenotypeJournal of Cell Science, 2006
- An antiviral role for the RNA interference machinery in Caenorhabditis elegansProceedings of the National Academy of Sciences of the United States of America, 2005
- RNA interference and plant parasitic nematodesTrends in Plant Science, 2005
- Capillary feeding of specific dsRNA induces silencing of the isac gene in nymphal Ixodes scapularis ticksInsect Molecular Biology, 2005
- Plasmodesmata as a supracellular control network in plantsNature Reviews Molecular Cell Biology, 2004
- The Genome Sequence of Caenorhabditis briggsae: A Platform for Comparative GenomicsPLoS Biology, 2003
- Genomic Analysis of Gene Expression in C. elegansScience, 2000
- Fine structure of the Caenorhabditis elegans secretory—excretory systemJournal of Ultrastructure Research, 1983