Cooperative Friedel−Crafts Catalysis in Heterobimetallic Regime: Alkylation of Aromatics by π-Activated Alcohols
- 6 April 2005
- journal article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 127 (17), 6162-6163
- https://doi.org/10.1021/ja0506004
Abstract
The highly active Friedel−Crafts alkylation (FCA) catalyst, [Ir(COD)Cl(SnCl3)(SnCl4)(arene)]+Cl- (1-SnCl 4), is easily generated in one-pot from [Ir(COD)Cl]2 or [Ir(COD)(μ-Cl)Cl(SnCl3)]2 (1) and SnCl4. The reaction of arenes, heteroarenes with benzyl, and allyl alcohols is promoted by 1-SnCl 4 (1 mol %) with high turnover frequency. Kinetic evidence is presented to establish FCA pattern. From dual-catalyst combination studies varying the transition metal and main group metal partner, the efficiency of the present catalysts is attributed to the electrophilic “IrIII−SnIV” core.Keywords
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