Mobilization of bone marrow-derived stem cells after myocardial infarction and left ventricular function
Open Access
- 25 February 2005
- journal article
- research article
- Published by Oxford University Press (OUP) in European Heart Journal
- Vol. 26 (12), 1196-1204
- https://doi.org/10.1093/eurheartj/ehi164
Abstract
Aims Recent data suggest that the administration of bone marrow-derived stem cells (BMSC) might improve myocardial perfusion and left ventricular (LV) function after acute myocardial infarction (AMI). The aim of this study was to assess spontaneous mobilization of BMSC expressing the haematopoietic and endothelial progenitor cell-associated antigen CD34+ after AMI and its relation to post-infarction remodelling. Methods and results Peripheral blood concentration of CD34+ BMSC was measured by flow cytometry in 54 patients with AMI, 26 patients with chronic stable angina (CSA), and 43 normal healthy subjects. In patients with AMI, LV function was measured by 2D-echocardiography. Eighteen AMI patients were reassessed at 1 year. BMSC concentration was higher in patients with AMI (mean peak value: 7.04±6.27 cells/µL), than in patients with CSA (3.80±2.12 cells/µL, P=0.036) and in healthy controls (1.87±1.52 cells/µL, PPP=0.048) and anterior AMI (P=0.05) were the only independent predictors of increased BMSC mobilization after AMI. In the 28 patients without subsequent acute coronary events reassessed at 1 year follow-up, CD34+ cell concentration was an independent predictor of global and regional improvement of LV function (r=0.52, P=0.004 and r=−0.41, P=0.03, respectively). Conclusion AMI is followed by enhanced spontaneous mobilization of BMSC, in particular, in patients on statin therapy and following a primary percutaneous intervention. More importantly persistent spontaneous mobilization of BMSC might contribute to determine a more favourable post-AMI remodelling.Keywords
This publication has 29 references indexed in Scilit:
- Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarctsNature, 2004
- Bone Marrow–Derived Cardiomyocytes Are Present in Adult Human HeartCirculation, 2003
- Autologous bone-marrow stem-cell transplantation for myocardial regenerationThe Lancet, 2003
- Transplantation of Progenitor Cells and Regeneration Enhancement in Acute Myocardial Infarction (TOPCARE-AMI)Circulation, 2002
- Repair of Infarcted Myocardium by Autologous Intracoronary Mononuclear Bone Marrow Cell Transplantation in HumansCirculation, 2002
- Chimerism of the Transplanted HeartNew England Journal of Medicine, 2002
- Mobilized bone marrow cells repair the infarcted heart, improving function and survivalProceedings of the National Academy of Sciences of the United States of America, 2001
- Evidence That Human Cardiac Myocytes Divide after Myocardial InfarctionNew England Journal of Medicine, 2001
- Bone marrow cells regenerate infarcted myocardiumNature, 2001
- Neovascularization of ischemic myocardium by human bone-marrow–derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac functionNature Medicine, 2001