The relevance of a hypoxic tumour microenvironment in prostate cancer
- 16 December 2009
- journal article
- review article
- Published by Wiley in BJU International
- Vol. 105 (1), 8-13
- https://doi.org/10.1111/j.1464-410x.2009.08921.x
Abstract
Research into the hypoxic tumour microenvironment is accelerating and the reversal of hypoxia is increasingly being suggested as a mechanism for improving cancer treatment. Recent studies have suggested that hypoxia is also a feature in prostate cancer and is associated with a poor prognosis. Hypoxia has been shown to cause radio-resistance and hence hamper one of the major treatments for prostate cancer. However, unlike other solid tumours, such as cervical and head-and-neck cancer, there are inconsistencies and unanswered questions about the relevance of hypoxia in prostate cancer. This review outlines the role of low-oxygen conditions in prostate cancer and the areas where further studies are required.Keywords
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