Multistability and Clustering in a Population of Synthetic Genetic Oscillators via Phase-Repulsive Cell-to-Cell Communication
- 2 October 2007
- journal article
- research article
- Published by American Physical Society (APS) in Physical Review Letters
- Vol. 99 (14), 148103
- https://doi.org/10.1103/physrevlett.99.148103
Abstract
We show that phase-repulsive coupling eliminates oscillations in a population of synthetic genetic clocks. For this, we propose an experimentally feasible synthetic genetic network that contains phase repulsively coupled repressilators with broken temporal symmetry. As the coupling strength increases, silencing of oscillations is found to occur via the appearance of an inhomogeneous limit cycle, followed by oscillation death. Two types of oscillation death are observed: For lower couplings, the cells cluster in one of two stationary states of protein expression; for larger couplings, all cells end up in a single (stationary) cellular state. Several multistable regimes are observed along this route to oscillation death.Keywords
This publication has 23 references indexed in Scilit:
- Reconstruction of genetic circuitsNature, 2005
- Modeling a synthetic multicellular clock: Repressilators coupled by quorum sensingProceedings of the National Academy of Sciences of the United States of America, 2004
- Diversity within a BirdsongPhysical Review Letters, 2002
- Engineered gene circuitsNature, 2002
- Synchronization of hyperexcitable systems with phase-repulsive couplingPhysical Review E, 2001
- A synthetic oscillatory network of transcriptional regulatorsNature, 2000
- Dephasing and Bursting in Coupled Neural OscillatorsPhysical Review Letters, 1995
- The jamming avoidance response in Eigenmannia is controlled by two separate motor pathwaysJournal of Neuroscience, 1993
- Birhythmicity in a system of two coupled identical oscillatorsPhysics Letters A, 1991
- From Clocks to ChaosPublished by Walter de Gruyter GmbH ,1988