Disrupting the Pairing Between let-7 and Hmga2 Enhances Oncogenic Transformation
- 16 March 2007
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 315 (5818), 1576-1579
- https://doi.org/10.1126/science.1137999
Abstract
MicroRNAs (miRNAs) are ∼22-nucleotide RNAs that can pair to sites within messenger RNAs to specify posttranscriptional repression of these messages. Aberrant miRNA expression can contribute to tumorigenesis, but which of the many miRNA-target relationships are relevant to this process has been unclear. Here, we report that chromosomal translocations previously associated with human tumors disrupt repression of High Mobility Group A2 ( Hmga2 ) by let-7 miRNA. This disrupted repression promotes anchorage-independent growth, a characteristic of oncogenic transformation. Thus, losing miRNA-directed repression of an oncogene provides a mechanism for tumorigenesis, and disrupting a single miRNA-target interaction can produce an observable phenotype in mammalian cells.Keywords
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