White Matter Atrophy and Cognitive Dysfunctions in Neuromyelitis Optica
Open Access
- 3 April 2012
- journal article
- research article
- Published by Public Library of Science (PLoS) in PLOS ONE
- Vol. 7 (4), e33878
- https://doi.org/10.1371/journal.pone.0033878
Abstract
Neuromyelitis optica (NMO) is an inflammatory disease of central nervous system characterized by optic neuritis and longitudinally extensive acute transverse myelitis. NMO patients have cognitive dysfunctions but other clinical symptoms of brain origin are rare. In the present study, we aimed to investigate cognitive functions and brain volume in NMO. The study population consisted of 28 patients with NMO and 28 healthy control subjects matched for age, sex and educational level. We applied a French translation of the Brief Repeatable Battery (BRB-N) to the NMO patients. Using SIENAx for global brain volume (Grey Matter, GM; White Matter, WM; and whole brain) and VBM for focal brain volume (GM and WM), NMO patients and controls were compared. Voxel-level correlations between diminished brain concentration and cognitive performance for each tests were performed. Focal and global brain volume of NMO patients with and without cognitive impairment were also compared. Fifteen NMO patients (54%) had cognitive impairment with memory, executive function, attention and speed of information processing deficits. Global and focal brain atrophy of WM but not Grey Matter (GM) was found in the NMO patients group. The focal WM atrophy included the optic chiasm, pons, cerebellum, the corpus callosum and parts of the frontal, temporal and parietal lobes, including superior longitudinal fascicle. Visual memory, verbal memory, speed of information processing, short-term memory and executive functions were correlated to focal WM volumes. The comparison of patients with, to patients without cognitive impairment showed a clear decrease of global and focal WM, including brainstem, corticospinal tracts, corpus callosum but also superior and inferior longitudinal fascicles. Cognitive impairment in NMO patients is correlated to the decreased of global and focal WM volume of the brain. Further studies are needed to better understand the precise origin of cognitive impairment in NMO patients, particularly in the WM.Keywords
This publication has 41 references indexed in Scilit:
- Areas of left perisylvian cortex mediate auditory–verbal short-term memoryNeuropsychologia, 2011
- Absence of cortical demyelination in neuromyelitis opticaNeurology, 2010
- Evaluation of brain atrophy estimation algorithms using simulated ground-truth dataMedical Image Analysis, 2010
- Magnetic resonance spectroscopy evaluation in patients with neuromyelitis opticaJournal of Neurology, Neurosurgery & Psychiatry, 2010
- MRI of the corpus callosum in multiple sclerosis: association with disabilityMultiple Sclerosis Journal, 2010
- Towards a functional organization of the medial temporal lobe memory system: Role of the parahippocampal and medial entorhinal cortical areasHippocampus, 2008
- The parietal cortex and episodic memory: an attentional accountNature Reviews Neuroscience, 2008
- Neuromyelitis optica with clinical and histopathological involvement of the brainMultiple Sclerosis Journal, 2007
- Reversible Verbal and Visual Memory Deficits after Left Retrosplenial InfarctionJournal of Clinical Neurology, 2007
- Rating neurologic impairment in multiple sclerosisNeurology, 1983