Regulation of muscle growth in neonates
- 1 January 2009
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in Current Opinion in Clinical Nutrition and Metabolic Care
- Vol. 12 (1), 78-85
- https://doi.org/10.1097/mco.0b013e32831cef9f
Abstract
Purpose of review This review reports recent findings on the multiple factors that regulate skeletal muscle growth in neonates. Recent findings Skeletal muscle is the fastest growing protein mass in neonates. The high rate of neonatal muscle growth is due to accelerated rates of protein synthesis accompanied by the rapid accumulation of muscle nuclei. Feeding profoundly stimulates muscle protein synthesis in neonates and the response decreases with age. The feeding-induced stimulation of muscle protein synthesis is modulated by enhanced sensitivity to the postprandial rise in insulin and amino acids. Insulin and amino acid signaling components have been identified that are involved in the feeding-induced stimulation of protein synthesis in neonatal muscle. The enhanced activation of these signaling components in skeletal muscle of the neonate contributes to the high rate of muscle protein synthesis and rapid gain in muscle protein mass in neonates. Summary Recent findings suggest that the immature muscle has a heightened capacity to activate signaling cascades that promote translation initiation in response to the postprandial rise in insulin and amino acids thereby enabling their efficient utilization for muscle growth. This capacity is further supported by enhanced satellite cell proliferation, but how these two processes are linked remains to be established.Keywords
This publication has 90 references indexed in Scilit:
- Leucine stimulates protein synthesis in skeletal muscle of neonatal pigs by enhancing mTORC1 activationAmerican Journal of Physiology-Endocrinology and Metabolism, 2008
- Canonical Wnt signalling induces satellite-cell proliferation during adult skeletal muscle regenerationJournal of Cell Science, 2008
- Differential regulation of protein synthesis by amino acids and insulin in peripheral and visceral tissues of neonatal pigsAmino Acids, 2008
- Niche Regulation of Muscle Satellite Cell Self-Renewal and DifferentiationCell Stem Cell, 2008
- A Temporal Switch from Notch to Wnt Signaling in Muscle Stem Cells Is Necessary for Normal Adult MyogenesisCell Stem Cell, 2008
- Activation by insulin and amino acids of signaling components leading to translation initiation in skeletal muscle of neonatal pigs is developmentally regulatedAmerican Journal of Physiology-Endocrinology and Metabolism, 2007
- Amino acid availability and age affect the leucine stimulation of protein synthesis and eIF4F formation in muscleAmerican Journal of Physiology-Endocrinology and Metabolism, 2007
- Glucose stimulates protein synthesis in skeletal muscle of neonatal pigs through an AMPK- and mTOR-independent processAmerican Journal of Physiology-Endocrinology and Metabolism, 2007
- Upstream of the mammalian target of rapamycin: do all roads pass through mTOR?Oncogene, 2006
- The regulation of Notch signaling in muscle stem cell activation and postnatal myogenesisSeminars in Cell & Developmental Biology, 2005