Guidelines for the performance of fusion procedures for degenerative disease of the lumbar spine. Part 16: bone graft extenders and substitutes
- 1 June 2005
- journal article
- guideline
- Published by Journal of Neurosurgery Publishing Group (JNSPG) in Journal of Neurosurgery: Spine
- Vol. 2 (6), 733-736
- https://doi.org/10.3171/spi.2005.2.6.0733
Abstract
Despite the large volume of animal data regarding the use of synthetic bone graft substitutes or extenders, there are very few data regarding the use of these substances for fusion in lumbar degenerative disease. The best available data indicate that rhBMP-2 is a viable alternative to autograft bone for interbody fusion procedures. This same substance may also be a viable alternative to autograft for PLF; however, definitive medical evidence is not yet available. There is little, if any, medical evidence to support the use of other biological agents at the present time. As promising new compounds are brought to market, well-designed cohort studies and randomized trials will be required to determine the actual usefulness of these compounds in clinical practice. It is important not to generalize the results obtained with one preparation or application to different preparations or applications. The use of synthetic calcium phosphate ceramics as graft extenders appears to be reasonable in certain situations. The medical evidence available regarding their use is limited and of poor quality. Further study will be required to establish their utility for use in spinal fusion.Keywords
This publication has 8 references indexed in Scilit:
- Is INFUSE Bone Graft Superior to Autograft Bone? An Integrated Analysis of Clinical Trials Using the LT-CAGE Lumbar Tapered Fusion DeviceJournal of Spinal Disorders & Techniques, 2003
- Mixture Ratios of Local Bone to Artificial Bone in Lumbar Posterolateral FusionJournal of Spinal Disorders & Techniques, 2003
- Use of Recombinant Human Bone Morphogenetic Protein-2 to Achieve Posterolateral Lumbar Spine Fusion in HumansSpine, 2002
- Anterior Lumbar Interbody Fusion with Processed Sea Coral (Coralline Hydroxyapatite) as Part of a Circumferential FusionSpine, 2002
- Anterior Lumbar Interbody Fusion Using rhBMP-2 With Tapered Interbody CagesJournal of Spinal Disorders & Techniques, 2002
- Use of an Advanced Formulation of β-Tricalcium Phosphate as a Bone Extender in Interbody Lumbar FusionPublished by SLACK, Inc. ,2002
- Instrumented posterolateral lumbar fusion using coralline hydroxyapatite with or without demineralized bone matrix, as an adjunct to autologous boneThe Spine Journal, 2001
- Use of autologous growth factors in lumbar spinal fusionBone, 1999