Difference in symptom severity between early and late grass pollen season in patients with seasonal allergic rhinitis
Open Access
- 1 January 2011
- journal article
- research article
- Published by Wiley in Clinical and Translational Allergy
- Vol. 1 (1), 18
- https://doi.org/10.1186/2045-7022-1-18
Abstract
For the development of forecasts for seasonal allergic rhinitis symptoms, it is essential to understand the relationship between grass pollen concentrations and the symptoms of grass pollen allergic patients. The aim of this study was to delineate this relationship between seasonal allergic rhinitis symptoms and grass pollen concentrations in the Netherlands. Grass pollen allergic patients (n = 80 [2007] - 84 [2008]) were enrolled into the study. They were asked to enter their seasonal allergic rhinitis symptoms (runny nose, sneezing, blocked nose, post nasal drip, and eye symptoms) daily on a scale from 0 to 3 to the study centre either by short message service (SMS) or by internet from May-July 2007 and April-July 2008. Daily pollen counts were used to define the early and the late grass pollen season as the period 'before and during' respectively 'after' the first grass pollen peak (more than 150 pollen/m3). At similar grass pollen concentrations, the daily mean of the individual maximum symptom scores reported in the early season were higher as compared to that reported in the late season [differences of -0.41 (2007) and -0.30 (2008)]. This difference could not be explained by medication use by the patients nor by co-sensitization to birch. We conclude that seasonal allergic rhinitis symptoms at similar grass pollen concentrations are more severe in the early flowering season as compared to those in the late flowering season. This finding is not only relevant for development of forecasts for seasonal allergic rhinitis symptoms but also for understanding symptom development and planning and analysis of clinical studies.Keywords
This publication has 21 references indexed in Scilit:
- GA2LEN/EAACI pocket guide for allergen‐specific immunotherapy for allergic rhinitis and asthmaAllergy, 2010
- GA2LEN skin test study II: clinical relevance of inhalant allergen sensitizations in EuropeAllergy, 2009
- Evidence-based study design in ocular allergy trialsCurrent Opinion in Allergy and Clinical Immunology, 2008
- Mechanisms of allergen specific immunotherapy – T‐cell tolerance and moreAllergy, 2006
- Clinical trial design, nasal allergen challenge models, and considerations of relevance to pediatrics, nasal polyposis, and different classes of medicationJournal of Allergy and Clinical Immunology, 2005
- Characteristics and Immunobiology of Grass Pollen AllergensInternational Archives of Allergy and Immunology, 2003
- Long-Term Clinical Efficacy of Grass-Pollen ImmunotherapyThe New England Journal of Medicine, 1999
- Observations on the pathogenesis of nasal primingJournal of Allergy and Clinical Immunology, 1989
- The seasonal symptoms of hyposensitized and untreated hay fever patients in relation to birch pollen counts: correlations with nasal sensitivity, prick tests and RASTClinical and Experimental Allergy, 1978
- Content of Pollen and Spores in the Air. Meteorological Conditions and Hay-fever ComplaintsORL, 1958