Leukemogenic Activity of Filtrates from Radiation-Induced Lymphoid Tumors of Mice
- 14 August 1959
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 130 (3372), 387-388
- https://doi.org/10.1126/science.130.3372.387
Abstract
Cell-free filtrates of x-ray-induced lymphoid tumors of strain C57BL/ Ka mice have elicited, on injection into newborn isologous hosts, a lymphoma incidence of 15 to 19 percent. In control mice of the same subline, the incidence of spontaneous lymphoma is about 1 percent. No leukemogenic activity could be detected in filtrates from thymi harvested at 2 to 32 days following completion of x-ray treatment. Activity was evident at 64 days and was perhaps somewhat greater at 128 days. Serial cell-free passage of filtrates in newborn F1 hybrid mice resulted in a marked increase in lymphoma incidence (69 percent), coupled with a shortening of the median latency. Supplementary x-irradiation failed to enhance the activity of filtrates after neonatal injection.Keywords
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