Prenylated Polyhydroxy-p-terphenyls from Aspergillus taichungensis ZHN-7-07

Abstract

Six new prenylated polyhydroxy-p-terphenyl metabolites, named prenylterphenyllins A−C (1−3) and prenylcandidusins A−C (5−7), and one new polyhydroxy-p-terphenyl with a simple tricyclic C-18 skeleton, named 4′′-dehydro-3-hydroxyterphenyllin (4), were obtained together with eight known analogues (8−15) from Aspergillus taichungensis ZHN-7-07, a root soil fungus isolated from the mangrove plant Acrostichum aureum. Their structures were determined by spectroscopic methods, and their cytotoxicity was evaluated using HL-60, A-549, and P-388 cell lines. Compounds 1 and 8 exhibited moderate activities against all three cell lines (IC₅₀ 1.53−10.90 μM), whereas compounds 4 and 6 displayed moderate activities only against the P-388 cell line (IC₅₀ of 2.70 and 1.57 μM, respectively).